التفاصيل البيبلوغرافية
| العنوان: |
Preliminary investigation of serum cardiac troponin I in dogs with acute ischaemic stroke. |
| المؤلفون: |
Gonçalves, R., Sanchez‐Masian, D., Maddox, T. W., Dukes‐McEwan, J. |
| المصدر: |
Journal of Small Animal Practice; Feb2020, Vol. 61 Issue 2, p93-100, 8p |
| مصطلحات موضوعية: |
TROPONIN I, DOGS, INVESTIGATIONS, STROKE, SERUM |
| مستخلص: |
Objectives: To describe the incidence of elevated serum cardiac troponin I in dogs with acute ischaemic strokes, to evaluate its prognostic value in these patients and characterise a possible relationship between cardiac troponin I elevation in dogs with ischaemic strokes and underlying cardiac dysfunction. Materials and Methods: Prospective study of 18 dogs with acute ischaemic stroke diagnosed by MRI of the brain. Serum cardiac troponin I concentration, trans‐thoracic echocardiography and six‐lead electrocardiography were performed and findings were compared between dogs with good and poor outcome. Results: Serum cardiac troponin I was increased in 17 dogs (median 0.95 ng/mL; range 0.146 to 153). Focal hyperechoic regions of myocardium were visible in two dogs using trans‐thoracic echocardiography and presumed to represent acute infarcts. A significant association was found between cardiac troponin I and creatinine concentrations. No difference in cardiac troponin I concentrations was detected between dogs that experienced good and poor outcomes. Clinically important cardiac dysfunction was identified in two dogs. Clinical Significance: Cardiac troponin I is commonly elevated in patients diagnosed with acute ischaemic stroke but, in this small study population, did not have prognostic value. Larger studies (recruiting a study population of 98 dogs for a power of 0.8 and a 0.05 alpha/critical value) would aid in further investigation of these preliminary results. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |