التفاصيل البيبلوغرافية
| العنوان: |
Doxorubicin, vinblastine, dacarbazine and lenalidomide for older Hodgkin lymphoma patients: final results of a German Hodgkin Study Group (GHSG) phase‐I trial. |
| المؤلفون: |
Böll, Boris, Plütschow, Annette, Bürkle, Carolin, Atta, Johannes, Pfreundschuh, Michael, Feuring‐Buske, Michaela, Vogelhuber, Martin, Sökler, Martin, Eichenauer, Dennis A., Thielen, Indra, Tresckow, Bastian, Fuchs, Michael, Engert, Andreas, Borchmann, Peter |
| المصدر: |
Angewandte Chemie; Apr2019, Vol. 131 Issue 15, p42-52, 11p |
| مصطلحات موضوعية: |
CANCER relapse, DOXORUBICIN, HODGKIN'S disease treatment, VINBLASTINE, DRUG overdose |
| مستخلص: |
Summary: About 30% of all Hodgkin lymphoma (HL) patients are ≥60 years old. As lenalidomide has promising single agent activity in multiple relapsed HL, we replaced bleomycin in ABVD with lenalidomide in this phase‐I trial. Patients aged ≥60 years with early‐unfavourable‐ or advanced‐stage HL (Eastern Cooperative Oncology Group performance status ≤2, Cumulative Illness Rating Scale for Geriatrics score 0–7) received 4–8 cycles of AVD (doxorubicin, vinblastine, dacarbazine) and lenalidomide in escalation with overdose control. Dose‐limiting toxicities (DLTs) included thromboembolism ≥grade 2, severe haematological toxicity, neutropenic fever and prolonged therapy delay. Twenty‐five patients with a median age of 68 years were included, 68% had advanced‐stage HL. A pre‐defined stopping criterion for dose escalation after DLT evaluation of 20/24 patients suggested a recommended phase II dose (RPTD) of 20 mg. DLTs occurred in 10/24 evaluable patients, all treated with ≥20 mg, however, median relative dose intensity was 97% (interquartile range 49–104%). Grade 3 or higher toxicities occurred in all 22 patients at ≥20 mg lenalidomide but no treatment‐related deaths occurred. Overall response rate was 80% for all patients (20/25) and 86% (19/22) at ≥20 mg lenalidomide. Three‐year estimates for progression‐free survival and OS were 69·7% (95% CI: 50·3–89·1%) and 83·8% (95%‐CI: 69·3–98·4%), respectively. In conclusion, AVD with lenalidomide 20 mg is feasible and highly effective in older HL patients. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |