التفاصيل البيبلوغرافية
| العنوان: |
EUS-Guided Intragastric Injection of Botulinum Toxin A in the Preoperative Treatment of Super-Obese Patients: a Randomized Clinical Trial. |
| المؤلفون: |
de Moura, Eduardo Guimarães Hourneaux, Ribeiro, Igor Braga, Frazão, Mariana Souza Varela, Mestieri, Luiz Henrique Mazzonetto, de Moura, Diogo Turiani Hourneaux, Dal Bó, Creusa Maria Roveri, Brunaldi, Vitor Ottoboni, de Moura, Eduardo Turiani Hourneaux, Nunes, Gabriel Cairo, Bustamante, Fábio Alberto Castillo, dos Passos Galvão Neto, Manoel, Matuguma, Sergio Eiji, Bernardo, Wanderley Marques, Santo, Marco Aurélio |
| المصدر: |
Obesity Surgery; Jan2019, Vol. 29 Issue 1, p32-39, 8p |
| مصطلحات موضوعية: |
BOTULINUM A toxins, INJECTIONS, OBESITY treatment, PREOPERATIVE care, ENDOSCOPIC ultrasonography, GASTRIC emptying, OVERWEIGHT persons, CLINICAL trials |
| مستخلص: |
Background: Obesity is a disease that is highly prevalent in Brazil, and the associated comorbidities represent a major global public health challenge. Botulinum toxin type A (BTX-A) is a potent neurotoxin and inhibitor of gastric smooth muscle activity. In theory, BTX-A administration should promote early satiety and weight loss because it delays gastric emptying by inhibiting acetylcholine-mediated peristalsis, which is primarily responsible for gastric motility. Because results in the literature are discrepant, the efficacy of intragastric injections of BTX-A as a primary treatment for obesity remains unknown. The objective of this prospective, double-blind, single-center randomized study was to evaluate the effects of endoscopic ultrasound-guided intragastric BTX-A injections, as a bridge to bariatric surgery, in super-obese patients.Methods: Thirty-two super-obese patients were randomized to one of two groups: BTX-A, in which 200 units of BTX-A were injected into the gastric antrum and body; and control, in which the same injections were performed with 0.9% saline. Weight, body mass index (BMI), and loss of excess weight were measured monthly over a 6-month period. Gastric emptying scintigraphy was performed before and after the procedure.Results: The patients in both groups showed significant weight loss over the course of the study (p < 0.001). There were no statistically significant differences between the groups regarding weight loss, excess weight, total loss of excess weight, total weight loss, or change in BMI.Conclusions: Intragastric injection of BTX-A does not appear to be an effective method of achieving preoperative weight loss in super-obese patients. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |