التفاصيل البيبلوغرافية
| العنوان: |
Human Herpesvirus 8 in Perinatally HIV-infected Children with Interstitial Lung Disease. |
| المؤلفون: |
Scotta, Marcelo Comerlato, Fabro, Alexandre Todorovic, Machado, Paula Renata Lima, Ramos, Simone Gusmão, Cervi, Maria Célia, Fonseca, Benedito Antônio Lopes da, Motta, Fabrizio, Negrini, Bento Vidal de Moura, da Fonseca, Benedito Antônio Lopes |
| المصدر: |
Journal of Tropical Pediatrics; Oct2018, Vol. 64 Issue 5, p382-388, 7p |
| مصطلحات موضوعية: |
IMMUNOGLOBULINS, KAPOSI'S sarcoma-associated herpesvirus, KAPOSI'S sarcoma, LYMPH nodes, CASTLEMAN'S disease, HIV infection complications, COMPARATIVE studies, CYTOMEGALOVIRUS diseases, CYTOMEGALOVIRUSES, DNA, HERPESVIRUS diseases, HERPESVIRUSES, HIV infections, IMMUNOHISTOCHEMISTRY, INTERSTITIAL lung diseases, LUNGS, RESEARCH methodology, MEDICAL cooperation, POLYMERASE chain reaction, RESEARCH, VIRAL antibodies, EVALUATION research, DISEASE complications |
| مستخلص: |
Introduction: Human herpesvirus 8 (HHV-8) is associated with the pathogenesis of Kaposi Sarcoma and interstitial pneumonitis in adults. This study aims to evaluate association between HHV-8 and interstitial lung disease in HIV-infected children.Methods: HIV-infected children with interstitial pneumonitis underwent lung biopsies in a tertiary hospital and were investigated for HHV-8, Epstein-Barr virus (EBV) and cytomegalovirus (CMV) using polymerase chain reaction (PCR) and immunohistochemistry in lung tissue. Peripheral blood PCR was also performed for HHV-8.Results: From six patients included, PCR for HHV-8 was positive in lung samples in four children and in peripheral blood in one. PCR for EBV and CMV and immunohistochemical study for HHV-8, EBV and CMV in lung were negative in all patients.Conclusion: No previous cases of HHV-8-associated interstitial pneumonitis was described in HIV-infected children. An immunological disorder and an infectious agent might influence development of the lymphoid interstitial pneumonitis. HHV-8 may be this infectious trigger. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |