التفاصيل البيبلوغرافية
| العنوان: |
Imaging of Nanoparticle Distribution to Assess Treatments That Alter Delivery. |
| المؤلفون: |
Blocker, Stephanie J., Shields, Anthony F. |
| المصدر: |
Molecular Imaging & Biology; Jun2018, Vol. 20 Issue 3, p340-351, 12p |
| مصطلحات موضوعية: |
CANCER treatment, DRUG delivery systems, NANOMEDICINE, MOLECULAR diagnosis of cancer, PERMEABILITY (Biology) |
| مستخلص: |
Molecular imaging is a vital tool to non-invasively measure nanoparticle delivery to solid tumors. Despite the myriad of nanoparticles studied for cancer, successful applications of nanoparticles in humans is limited by inconsistent and ineffective delivery. Successful nanoparticle delivery in preclinical models is often attributed to enhanced permeability and retention (EPR)-a set of conditions that is heterogeneous and transient in patients. Thus, researchers are evaluating therapeutic strategies to modify nanoparticle delivery, particularly treatments which have demonstrated effects on EPR conditions. Imaging nanoparticle distribution provides a means to measure the effects of therapeutic intervention on nanoparticle delivery to solid tumors. This review focuses on the utility of imaging to measure treatment-induced changes in nanoparticle delivery to tumors and provides preclinical examples studying a broad range of therapeutic interventions. [ABSTRACT FROM AUTHOR] |
|
Copyright of Molecular Imaging & Biology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |