التفاصيل البيبلوغرافية
| العنوان: |
Reemergence of translocation t(11;19)(q23;p13.1) in the absence of clinically overt leukemia. |
| المؤلفون: |
Uemura, Suguru, Tamura, Akihiro, Saito, Atsuro, Hasegawa, Daiichiro, Nino, Nanako, Yokoi, Takehito, Tahara, Teppei, Kozaki, Aiko, Kishimoto, Kenji, Ishida, Toshiaki, Kawasaki, Keiichiro, Mori, Takeshi, Nishimura, Noriyuki, Ishimae, Minenori, Eguchi, Mariko, Kosaka, Yoshiyuki |
| المصدر: |
International Journal of Hematology; Dec2017, Vol. 106 Issue 6, p847-851, 5p |
| مستخلص: |
We report the case of a 10-year-old female with acute myeloid leukemia (AML) FAB M0 carrying a novel t(11;19)(q23;p13.1) MLL- ELL variant, in which intron 8 of MLL is fused to exon 6 of ELL. Complete remission, judged by morphology and cytogenetic analysis, was achieved after the conventional chemotherapy. Eight months after completion of therapy, the level of WT- 1 in peripheral blood and the number of cells with the MLL- ELL fusion transcript resurged. However, the patient remained overtly healthy and the morphology in the bone-marrow smear was innocuous, with no sign of relapse or secondary leukemia. Without any evidence of relapse, the patient has been closely observed without any therapeutic intervention. For approximately 2 years after the completion of therapy, despite clonal proliferation of pre-leukemic cells with an MLL- ELL fusion gene, she has maintained complete remission. In this case, the rare variant form of MLL- ELL fusion that has been identified may be related to diminished leukemogenic capacity, resulting in the persistence of pre-leukemic status; an additional genetic abnormality may thus be necessary for full transformation of pre-leukemic cells. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |