التفاصيل البيبلوغرافية
| العنوان: |
A Japanese prospective multi-institutional feasibility study on accelerated partial breast irradiation using interstitial brachytherapy: clinical results with a median follow-up of 26 months. |
| المؤلفون: |
Nose, Takayuki, Otani, Yuki, Asahi, Shuuji, Tsukiyama, Iwao, Dokiya, Takushi, Saeki, Toshiaki, Fukuda, Ichirou, Sekine, Hiroshi, Shikama, Naoto, Kumazaki, Yu, Takahashi, Takao, Yoshida, Ken, Kotsuma, Tadayuki, Masuda, Norikazu, Yoden, Eisaku, Nakashima, Kazutaka, Matsumura, Taisei, Nakagawa, Shino, Tachiiri, Seiji, Moriguchi, Yoshio |
| المصدر: |
Breast Cancer (13406868); Nov2016, Vol. 23 Issue 6, p861-868, 8p |
| مستخلص: |
Background: A Japanese prospective multi-institutional feasibility study on accelerated partial breast irradiation using interstitial brachytherapy was performed. The first clinical results were reported with a median follow-up of 26 months. Patients and methods: Forty-six female breast cancer patients with positive hormone receptors and tumors ≤3 cm, pN0M0, completed the protocol treatment. After breast-conserving surgery and histological confirmation of negative surgical margins and pN0, brachytherapy applicators were implanted either postoperatively ( n = 45) or intraoperatively ( n = 1). High-dose-rate brachytherapy of 36 Gy/6 fractions was delivered. All clinical data were prospectively collected using case report forms and the Common Terminology Criteria for Adverse Events ver.3.0. Results: At the median follow-up of 26 months, no breast cancer recurrence of any type was observed. Sequelae ≥G2 were dermatitis (G2, 7 %), fibrosis (G2, 11 %; G3, 4 %), fracture (G2, 2 %), pain (G2, 7 %; G3, 2 %), and soft tissue necrosis (G2, 6 %). Cosmetic outcomes evaluated by excellent/good scores were 100 % at pre-therapy ( n = 46), 94 % at 12 months ( n = 46), and 81 % at 24 months ( n = 36), respectively. Conclusions: Disease control and sequelae were satisfactory due to the strict eligibility and protocol-defined treatment parameters. The cosmetic outcomes were comparable to those of previous Japanese breast-conserving therapy series. [ABSTRACT FROM AUTHOR] |
|
Copyright of Breast Cancer (13406868) is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |