التفاصيل البيبلوغرافية
| العنوان: |
Variants in the SIRT1 gene may affect diabetes risk in interaction with prenatal exposure to famine. |
| المؤلفون: |
Botden IP, Zillikens MC, de Rooij SR, Langendonk JG, Danser AH, Sijbrands EJ, Roseboom TJ, Botden, Ilse P G, Zillikens, M Carola, de Rooij, Susanne R, Langendonk, Janneke G, Danser, A H Jan, Sijbrands, Eric J G, Roseboom, Tessa J |
| المصدر: |
Diabetes Care; Feb2012, Vol. 35 Issue 2, p424-426, 3p |
| مستخلص: |
Objective: To investigate whether SIRT1, a nutrient-sensing histone deacetylase, influences fetal programming during malnutrition.Research Design and Methods: In 793 individuals of the Dutch Famine Birth Cohort, we analyzed the interaction between three SIRT1 single nucleotide polymorphisms (SNPs) and prenatal exposure to famine on type 2 diabetes risk.Results: In the total population (exposed and unexposed), SIRT1 variants were not associated with type 2 diabetes. A significant interaction was found between two SIRT1 SNPs and exposure to famine in utero on type 2 diabetes risk (P = 0.03 for rs7895833; P = 0.01 for rs1467568). Minor alleles of these SNPs were associated with a lower prevalence of type 2 diabetes only in individuals who had been exposed to famine prenatally (odds ratio for rs7895833 0.50 [95% CI 0.24-1.03], P = 0.06; for rs1467568 0.48 [0.25-0.91], P = 0.02).Conclusions: SIRT1 may be an important genetic factor involved in fetal programming during malnutrition, influencing type 2 diabetes risk later in life. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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