التفاصيل البيبلوغرافية
| العنوان: |
Etanercept. |
| المؤلفون: |
Lecluse, Lidian L. A., Dowlatshahi, Emmilia A., Limpens, Jacqueline M., de Rie, Menno A., Bos, Jan D., Spuls, Phyllis I. |
| المصدر: |
Archives of Dermatology; Jan2011, Vol. 147 Issue 1, p79-94, 16p |
| مستخلص: |
Objectives: To provide a comprehensive overview of dermatologic adverse events of etanercept described in the literature (including all study types, case reports, and surveys) and to present information on the occurrence, severity, treatment, and course of these adverse events. Data Sources: MEDLINE and EMBASE. Study Selection: All reports on individual patients who developed a dermatologic adverse event associated with systemic etanercept treatment for any indication in any type of original article were included. Data Extraction: All data were independently extracted by 2 reviewers. Disagreements were resolved by consensus. All articles included (except for case reports/ case series) were assessed regarding level of evidence. Data Synthesis: In 126 included study reports, a total of 72 separate specific dermatologic adverse events of etanercept were mentioned. In 101 case reports/case series, 153 individual patients with approximately 65 different specific diagnoses (eg, not rash) were reported. Conclusions: Etanercept is associated with a wide variety of dermatologic adverse events, many of which were described in study reports, but case reports also described numerous exceptional cases. Although the adverse events are usually mild, some reactions are serious and even potentially life threatening. Therefore, all drug-associated cutaneous abnormalities should be carefully evaluated. Diagnostic steps do not deviate from the norm in these patients, but management of the dermatologic adverse events may need special attention. [ABSTRACT FROM AUTHOR] |
|
Copyright of Archives of Dermatology is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |