التفاصيل البيبلوغرافية
| العنوان: |
Bayesian hierarchical model for dose-finding trial incorporating historical data. |
| المؤلفون: |
Han, Linxi1 (AUTHOR), Deng, Qiqi2 (AUTHOR), He, Zhangyi3 (AUTHOR), Fleischer, Frank4 (AUTHOR), Yu, Feng1 (AUTHOR) feng.yu@bristol.ac.uk |
| المصدر: |
Journal of Biopharmaceutical Statistics. Aug2024, Vol. 34 Issue 5, p646-660. 15p. |
| مصطلحات موضوعية: |
MULTIPLE comparisons (Statistics), PROGNOSTIC models, SAMPLE size (Statistics), HETEROGENEITY, PLACEBOS |
| مستخلص: |
The Multiple Comparison Procedure and Modelling (MCPMod) approach has been shown to be a powerful statistical technique that can significantly improve the design and analysis of dose-finding studies under model uncertainty. Due to its frequentist nature, however, it is difficult to incorporate information into MCPMod from historical trials on the same drug. BMCPMod, a recently introduced Bayesian version of MCPMod, is designed to take into account historical information on the placebo dose group. We introduce a Bayesian hierarchical framework capable of incorporating historical information on an arbitrary number of dose groups, including both placebo and active ones, taking into account the relationship between responses of these dose groups. Our approach can also model both prognostic and predictive between-trial heterogeneity and is particularly useful in situations where the effect sizes of two trials are different. Our goal is to reduce the necessary sample size in the dose-finding trial while maintaining its target power. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Business Source Index |