التفاصيل البيبلوغرافية
| العنوان: |
Unraveling Mechanisms that Control Platelet Production. |
| المؤلفون: |
Italiano Jr., Joseph E.1 jitaliano@rics.bwh.harvard.edu |
| المصدر: |
Seminars in Thrombosis & Hemostasis. Feb2013, Vol. 39 Issue 1, p15-24. 10p. |
| مصطلحات موضوعية: |
*BLOOD platelets, *MEGAKARYOCYTES, *BONE marrow, *CYTOSKELETON, *THROMBOCYTOPENIA |
| مستخلص: |
Platelets are formed by giant precursor cells called megakaryocytes that reside within the bone marrow. The generation of platelets, and their release into the bloodstream by megakaryocytes, requires a complex series of remodeling events powered by the cytoskeleton to result in the release of many platelets from a single megakaryocyte. Abnormalities in this process can result in thrombocytopenia (low platelet count) and can lead to increased risk of bleeding. This review describes the process of platelet production in detail and discusses new insights into novel platelet biology. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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