التفاصيل البيبلوغرافية
| العنوان: |
Spectrum of gr/gr and b2/b3 Y Chromosome Microdeletions in Pakistani Population. |
| المؤلفون: |
Mujtaba, Nosheen1, Siddiqui, Rubina Tabassum1 tabassum.rubina@gmail.com |
| المصدر: |
Pakistan Journal of Medical Sciences. Mar2011, Vol. 27 Issue 2, p384-387. 4p. 1 Black and White Photograph, 1 Graph. |
| مصطلحات موضوعية: |
*HUMAN genetics, *PAKISTANIS, *Y chromosome, *MALE infertility, *OLIGOSPERMIA, *GENETIC markers, *PATIENTS, *GENETICS |
| مستخلص: |
Objective: To evaluate the frequency and clinical significance of gr/gr and b2/b3 deletions in Pakistani population. Methodology: In this study, we analyzed Y chromosome deletions using markers sY1191 and sY1291 in patients with azoospermia (n=26), severe oligozoospermia (n=29), moderate oligozoospermia (n=24) and normozoospermia (n=9) using multiplex PCR. Control group consisted of fertile men with normal spermatogenesis (n=30) having children. Results: The overall deletion frequency of gr/gr was 6.8 % (6 /88) while that of b2/b3 was 5.6 % (5/88). gr/gr deletions were detected in 4 men with severe oligozoospermia, 1 with azoospermia and 1 normospermic (but infertile) man. b2/b3 deletion was found in 3 severe oligozoospermic and 2 azoospermic men. None of the control group had either gr/gr or b2/b3 deletion. Conclusion: Our results indicate that both gr/gr and b2/b3 deletions are a risk factor for spermatogenic failure in the population under study. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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