التفاصيل البيبلوغرافية
| العنوان: |
Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation |
| المؤلفون: |
Fu, Lei1,2, Yun, Francisco1, Oczak, Marko1, Wong, Betty Y.L.2, Vieth, Reinhold1,3, Cole, David E.C.1,2,4,5 davidec.cole@utoronto.ca |
| المصدر: |
Clinical Biochemistry. Jul2009, Vol. 42 Issue 10/11, p1174-1177. 4p. |
| مصطلحات موضوعية: |
*VITAMIN D, *CALCIUM regulating hormones, *STEROID hormones, *FAT-soluble vitamins |
| مستخلص: |
Abstract: Background: To determine the effect of vitamin D binding protein (DBP) genotypes on 25-hydroxyvitamin D [25(OH)D] changes with vitamin D supplements, we studied 98 adults receiving 600 or 4000 IU/d vitamin D3 for one year. Methods: The DBP functional variant, T436K, was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: Mean 25(OH)D increases were 97% for TT (n =48), 151% for TK (n =31) and 307% (n =6) for KK genotypes (p =.004). Conclusions: As with baseline 25(OH)D, T436K genotype predicts 25(OH)D changes after long-term vitamin D supplementation. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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