التفاصيل البيبلوغرافية
| العنوان: |
MscS, the bacterial mechanosensitive channel of small conductance |
| المؤلفون: |
Hurst, Annette C.1 a.hurst@uq.edu.au, Petrov, Evgeny1 petrov67@yahoo.com, Kloda, Anna1 a.kloda@uq.edu.au, Nguyen, Thom2 thom.nmn@gmail.com, Hool, Livia2 lhool@cyllene.uwa.edu.au, Martinac, Boris1 b.martinac@uq.edu.au |
| المصدر: |
International Journal of Biochemistry & Cell Biology. Apr2008, Vol. 40 Issue 4, p581-585. 5p. |
| مصطلحات موضوعية: |
*PROKARYOTES, *PHYSIOLOGICAL effects of chemicals, *ANTI-infective agents, *MEDICAL sciences |
| مستخلص: |
Abstract: The mechanosensitive channel of small conductance, MscS, is one of the most extensively studied MS channels to date. Past and present research involves the discovery of its physiological role as an emergency valve in prokaryotes up to detailed investigations of its conductive properties and gating mechanism. In this review, we summarize the findings on its structure and function obtained by experimental and theoretical approaches. A special focus is given to its pharmacology, since various compounds have been shown to affect the activity of this channel. These compounds have particularly been helpful for understanding the interaction of MscS with the lipid bilayer, as well as recognizing the potential of this channel as a target for novel types of antibiotics. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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