التفاصيل البيبلوغرافية
| العنوان: |
Effects of the free radical scavenger, edaravone, on the development of postoperative cognitive impairment in patients undergoing carotid endarterectomy |
| المؤلفون: |
Ogasawara, Kuniaki1,2 kuogasa@iwate-med.ac.jp, Yamadate, Keiko3, Kobayashi, Masakazu1,2, Endo, Hidehiko1,2, Fukuda, Takeshi1,2, Yoshida, Kenji1,2, Terasaki, Kazunori2, Inoue, Takashi1,2, Ogawa, Akira1,2 |
| المصدر: |
Surgical Neurology. Oct2005, Vol. 64 Issue 4, p309-313. 5p. |
| مصطلحات موضوعية: |
*ENDARTERECTOMY, *ARTERIAL surgery, *BLOOD circulation, *TOMOGRAPHY |
| مستخلص: |
Abstract: Background: Some patients undergoing carotid endarterectomy (CEA) experience postoperative cognitive impairment. The purpose of the present case cohort study with historical control was to determine whether pretreatment with a novel free radical scavenger, edaravone, could prevent development of cognitive impairment after CEA. Methods: Fifty-five patients with ipsilateral internal carotid artery (ICA) stenosis (≥70%) underwent CEA with administration of edaravone before ICA clamping. Neuropsychological testing was performed preoperatively and at the first postoperative month. Cerebral blood flow was also measured using single-photon emission computed tomography before and immediately after CEA and on the third postoperative day. Results: Postoperative cognitive impairment was observed in only 1 (2%) patient, who exhibited postoperative cerebral hyperperfusion (cerebral blood flow increase ≥100% compared with preoperative values). Incidence of postoperative cognitive impairment in the control group (92 CEA patients without administration of edaravone) was significantly higher (12%) (P = .0298, control vs treatment group). Logistic regression analysis demonstrated that postoperative cerebral hyperperfusion and absence of pretreatment with edaravone were significant independent predictors of postoperative cognitive impairment. Conclusion: Pretreatment with edaravone can prevent development of cognitive impairment after CEA. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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