التفاصيل البيبلوغرافية
| العنوان: |
Spirooxindole-Pyrrolizidine: Synthesis, Crystal Structure, and Anticancer Activity. |
| المؤلفون: |
Jeyashri, K. R.1 (AUTHOR), Logeshwari, G.1 (AUTHOR), Sivakumar, K.2 (AUTHOR), Selvanayagam, S.3 (AUTHOR), Manikandan, H.1 (AUTHOR) profmani.au@gmail.com, Sakthivel, P.4 (AUTHOR), Thirunavukkarasu, V.5 (AUTHOR) |
| المصدر: |
Polycyclic Aromatic Compounds. Jan2025, p1-34. 34p. 16 Illustrations. |
| مصطلحات موضوعية: |
*ANTINEOPLASTIC agents, *HETEROCYCLIC compounds, *CELL lines, *X-ray diffraction, *CHEMICAL synthesis |
| مستخلص: |
AbstractThe nitrogen-containing heterocyclic compounds, in specific spiro-pyrrolizidine analogues were found to be effective in the cancer-fighting abilities, which also apply to spirooxindole-pyrrolidine. Hence, Motivated by the anticaner abilities of spiro-pyrrolizidine analogues, we devised a scheme employing 3,5-dibenzyloxy acetophenone and trimethoxy benzaldehyde for the synthesis of spirooxindole-pyrrolidine. Upon testing the synthesized 2′-(3,5-bis(benzyloxy)benzoyl)-1′-(3,4,5-trimethoxyphenyl)-1′,2′,5′,6′,7′,7a′-hexahydrospiro[indoline-3,3′-pyrrolizin]-2-one (compound 1) cancer cell lines exhibited significant anticancer efficacy with IC50 values 51.75 and 70.08 µM for MDA-MB 231 and HCT-116 cell lines respectively. The structure of the synthesized compound is elucidated with spectral and XRD data. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |