التفاصيل البيبلوغرافية
| العنوان: |
Organocatalytic Packed-Bed Reactors for the Enantioselective Flow Synthesis of Quaternary Isotetronic Acids by Direct Aldol Reactions of Pyruvates. |
| المؤلفون: |
Poletti, Lorenzo1 (AUTHOR) lorenzo.poletti@unife.it, De Risi, Carmela2 (AUTHOR) carmela.derisi@unife.it, Ragno, Daniele2 (AUTHOR) daniele.ragno@unife.it, Di Carmine, Graziano1 (AUTHOR) graziano.dicarmine@unife.it, Tassoni, Riccardo3 (AUTHOR) riccardo.tassoni@isof.cnr.it, Massi, Alessandro2 (AUTHOR) alessandro.massi@unife.it, Dambruoso, Paolo3 (AUTHOR) alessandro.massi@unife.it |
| المصدر: |
Molecules. Jan2025, Vol. 30 Issue 2, p296. 13p. |
| مصطلحات موضوعية: |
*FLOW chemistry, *BUTENOLIDES, *ALKYL group, *PYRUVATES, *ORGANOCATALYSIS |
| مستخلص: |
The utilization of the homogeneous (S)-2-pyrrolidine-tetrazole organocatalyst (Ley catalyst) in the self-condensation of ethyl pyruvate and cross-aldol reactions of ethyl pyruvate donor with non-enolizable pyruvate acceptors, namely the sterically hindered ethyl 3-methyl-2-oxobutyrate or the highly electrophilic methyl 3,3,3-trifluoropyruvate, is described as the key enantioselective step toward the synthesis of the corresponding biologically relevant isotetronic acids featuring a quaternary carbon functionalized with ester and alkyl groups. The transition from homogeneous to heterogeneous flow conditions is also investigated, detailing the fabrication and operation of packed-bed reactors filled with a silica-supported version of the pyrrolidine-tetrazole catalyst (SBA-15 as the matrix). [ABSTRACT FROM AUTHOR] |
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