التفاصيل البيبلوغرافية
| العنوان: |
Identification of a novel TOP2B::AFF2 fusion gene in B-cell acute lymphoblastic leukemia. |
| المؤلفون: |
Liu, Tao1 (AUTHOR), Wang, Yang1,2 (AUTHOR), An, Xi-Zhou1 (AUTHOR), Liu, Jiaqi3 (AUTHOR), Wu, Yuqin4 (AUTHOR), Xiang, Yan1 (AUTHOR), Zhang, Yong-Jie1 (AUTHOR), Huang, Lan1 (AUTHOR), Li, Jia-Cheng1 (AUTHOR), Li, Yu-Zhuo-Pu1 (AUTHOR), Yu, Jie1 (AUTHOR) yujie@hospital.cqmu.edu.cn |
| المصدر: |
Scientific Reports. 1/25/2025, Vol. 15 Issue 1, p1-9. 9p. |
| مصطلحات موضوعية: |
*GENE fusion, *LYMPHOBLASTIC leukemia, *PHASE transitions, *ACUTE leukemia, *CELL cycle |
| مستخلص: |
Genetic alterations play a pivotal role in leukemic clonal transformation, significantly influencing disease pathogenesis and clinical outcomes. Here, we report a novel fusion gene and investigate its pathogenic role in acute lymphoblastic leukemia (ALL). We engineer a transposon transfection system expressing the TOP2B::AFF2 transcript and introduce it into Ba/F3 cells. Functional studies, including proliferation, cell cycle, and apoptosis assays, were conducted to assess the fusion gene's impact. In vitro assays reveal that the TOP2B::AFF2 fusion significantly enhances Ba/F3 cell proliferation and G1/S phase transition while suppressing differentiation and apoptosis. This study identifies TOP2B::AFF2 as a potential oncogenic driver. However, further validation through in vivo studies are warranted to fully elucidate the fusion gene's role in leukemogenesis. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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