| مستخلص: |
The document discusses the critical role of signaling pathways in liver diseases, such as hepatitis, cirrhosis, fatty liver disease, and hepatocellular carcinoma, which contribute to significant morbidity and mortality globally. It highlights the intricate pathogenesis of liver diseases influenced by genetic predisposition, environmental exposures, metabolic disturbances, and immune system dysregulation. The document emphasizes recent advancements in understanding signaling cascades like MAPK, NF-κB, TGF-β, and apoptotic pathways, offering insights into potential therapeutic interventions. The research presented involves 110 authors from eight countries, providing a comprehensive overview of signaling mechanisms in liver pathology, aiming to enhance understanding and develop effective management strategies for liver diseases. [Extracted from the article] |
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