التفاصيل البيبلوغرافية
| العنوان: |
Superior Anti-Tumor Response After Microbeam and Minibeam Radiation Therapy in a Lung Cancer Mouse Model. |
| المؤلفون: |
Subramanian, Narayani1,2 (AUTHOR) narayani.subramanian@tum.de, Čolić, Aleksandra1,2 (AUTHOR) aleksandra.colic@helmholtz-munich.de, Santiago Franco, Marina1,2 (AUTHOR) marina.franco@tum.de, Stolz, Jessica1,2 (AUTHOR) jessica.stolz@tum.de, Ahmed, Mabroor1,2 (AUTHOR) mabroor.ahmed@helmholtz-munich.de, Bicher, Sandra1,2 (AUTHOR) sandra.bicher@tum.de, Winter, Johanna1,2 (AUTHOR) johanna.winter@tum.de, Lindner, Rainer2 (AUTHOR), Raulefs, Susanne1,2 (AUTHOR) susanne.raulefs@tum.de, Combs, Stephanie E.1,2 (AUTHOR) stephanie.combs@tum.de, Bartzsch, Stefan1,2 (AUTHOR) stefan.bartzsch@tum.de, Schmid, Thomas E.1,2 (AUTHOR) stefan.bartzsch@tum.de |
| المصدر: |
Cancers. Jan2025, Vol. 17 Issue 1, p114. 11p. |
| مصطلحات موضوعية: |
*BIOLOGICAL models, *RADIOTHERAPY, *RESEARCH funding, *RADIATION injuries, *CELL physiology, *TREATMENT effectiveness, *DESCRIPTIVE statistics, *MICE, *LUNG tumors, *ANIMAL experimentation, *RADIATION doses, *COMPARATIVE studies |
| مستخلص: |
Simple Summary: Radiation therapy is applied to approximately half of all cancer patients worldwide. For some tumors, its success is still limited due to radiation-sensitive organs at risk in the tumor's proximity and the occurrence of severe side effects in the surrounding normal tissue. Spatial fractionation is an innovative strategy that substantially reduces radiation-induced damage to normal tissues while effectively maintaining tumor control rates, leading to an increased therapeutic window. The aim of the present study was to determine the tumor growth delay in an in vivo xenograft mouse model, comparing novel spatial fractionated treatment modalities with conventional radiotherapy. We confirmed a significant reduction in tumor regrowth following all radiation modalities, with microbeam radiation therapy showing the most pronounced growth delay, followed by minibeam radiation therapy. Objectives: The present study aimed to compare the tumor growth delay between conventional radiotherapy (CRT) and the spatially fractionated modalities of microbeam radiation therapy (MRT) and minibeam radiation therapy (MBRT). In addition, we also determined the influence of beam width and the peak-to-valley dose ratio (PVDR) on tumor regrowth. Methods: A549, a human non-small-cell lung cancer cell line, was implanted subcutaneously into the hind leg of female CD1-Foxn1nu mice. The animals were irradiated with sham, CRT, MRT, or MBRT. The spatially fractionated fields were created using two specially designed multislit collimators with a beam width of 50 μm and a center-to-center distance (CTC) of 400 μm for MRT and a beam width of 500 μm and 2000 μm CTC for MBRT. Additionally, the concept of the equivalent uniform dose (EUD) was chosen in our study. A dose of 20 Gy was applied to all groups with a PVDR of 20 for MBRT and MRT. Tumor growth was recorded until the tumors reached at least a volume that was at least three-fold of their initial value, and the growth delay was calculated. Results: We saw a significant reduction in tumor regrowth following all radiation modalities. A growth delay of 11.1 ± 8 days was observed for CRT compared to the sham, whereas MBRT showed a delay of 20.2 ± 7.3 days. The most pronounced delay was observed in mice irradiated with MRT PVDR 20, with 34.9 ± 26.3 days of delay. Conclusions: The current study highlights the fact that MRT and MBRT modalities show a significant tumor growth delay in comparison to CRT at equivalent uniform doses. [ABSTRACT FROM AUTHOR] |
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