التفاصيل البيبلوغرافية
| العنوان: |
Molecular Insights on Signaling Cascades in Breast Cancer: A Comprehensive Review. |
| المؤلفون: |
Panda, Venketesh K.1,2 (AUTHOR) venketeshpanda1998@gmail.com, Mishra, Barnalee1 (AUTHOR) barnaleemishra12@gmail.com, Mahapatra, Samikshya1 (AUTHOR) samikshyamahapatra.ksbt50@gmail.com, Swain, Biswajit1 (AUTHOR) swainbiswajit555@gmail.com, Malhotra, Diksha1 (AUTHOR) diksha.ksbt@gmail.com, Saha, Suryendu1 (AUTHOR) suryendu.saha@gmail.com, Khanra, Sinjan1 (AUTHOR) sinjankhanra143@gmail.com, Mishra, Priyanka1 (AUTHOR) priyankamishra1994828@gmail.com, Majhi, Sambhunath1 (AUTHOR) smajhi034@gmail.com, Kumari, Kavita1 (AUTHOR) kavihumangenetics@gmail.com, Nath, Angitha N.1 (AUTHOR) nathankita61@gmail.com, Saha, Swarnali1 (AUTHOR) sahaswarnali2021@gmail.com, Jena, Sarmistha1 (AUTHOR) sarmisthajena99@gmail.com, Kundu, Gopal C.1,2,3 (AUTHOR) gopalc.kundu@kiit.ac.in |
| المصدر: |
Cancers. Jan2025, Vol. 17 Issue 2, p234. 41p. |
| مصطلحات موضوعية: |
*THERAPEUTIC use of antineoplastic agents, *NF-kappa B, *VASCULAR endothelial growth factors, *BREAST tumors, *CELL physiology, *IMMUNOTHERAPY, *APOPTOSIS, *CELLULAR signal transduction, *CANCER chemotherapy, *MOLECULAR biology, *NEOVASCULARIZATION |
| مستخلص: |
Simple Summary: Breast cancer is an intricate condition that is caused by aberrant cell signaling regulation induced by the accumulation of genetic and epigenetic alterations. It is well known that various downstream signaling cascades (JAK/STAT, PI3K/Akt, and MAPK) are activated in transformed cells to regulate tumor growth, angiogenesis, metastasis, therapy failure, and stemness. However, the complex signaling networks and their crosstalk is challenged by structural alterations, aberrant gene amplification, and activation of alternative pathways. The complex signaling network within the breast tumor microenvironment is crucial for its growth, metastasis, angiogenesis, therapy escape, stem cell maintenance, and immunomodulation. An array of secretory factors and their receptors activate downstream signaling cascades regulating breast cancer progression and metastasis. Among various signaling pathways, the EGFR, ER, Notch, and Hedgehog signaling pathways have recently been identified as crucial in terms of breast cancer proliferation, survival, differentiation, maintenance of CSCs, and therapy failure. These receptors mediate various downstream signaling pathways such as MAPK, including MEK/ERK signaling pathways that promote common pro-oncogenic signaling, whereas dysregulation of PI3K/Akt, Wnt/β-catenin, and JAK/STAT activates key oncogenic events such as drug resistance, CSC enrichment, and metabolic reprogramming. Additionally, these cascades orchestrate an intricate interplay between stromal cells, immune cells, and tumor cells. Metabolic reprogramming and adaptations contribute to aggressive breast cancer and are unresponsive to therapy. Herein, recent insights into the novel signaling pathways operating within the breast TME that aid in their advancement are emphasized and current developments in practices targeting the breast TME to enhance treatment efficacy are reviewed. [ABSTRACT FROM AUTHOR] |
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