التفاصيل البيبلوغرافية
| العنوان: |
糖尿病和血糖控制水平对结核病发病风险的影响: 基于人群的 队列研究. |
| Alternate Title: |
Effect of blood glucose control level on the incidence risk of tuberculosis: a population - based cohort study. |
| المؤلفون: |
连依琳1, 李 晨2, 卢 鹏3, 刘 巧3, 竺丽梅3, 洪 忻2, 羊海涛1 yanghtjscdc@163.com |
| المصدر: |
Journal of Nanjing Medical University: Natural Sciences. 2024, Vol. 44 Issue 12, p1723-1728. 6p. |
| مصطلحات موضوعية: |
*BLOOD sugar, *TUBERCULOSIS patients, *BLOOD grouping & crossmatching, *TUBERCULOSIS, *PEOPLE with diabetes, *PROPORTIONAL hazards models |
| Abstract (English): |
Objective: This study aims to investigate the effect of blood glucose control on tuberculosis risk. Methods: A 6- year cohort study was conducted on 60 283 subjects in Nanjing, Jiangsu Province. After excluding active tuberculosis patients identified during baseline screening, subjects were matched with the tuberculosis patient management information in Nanjing to identify active tuberculosis cases. The Cox proportional hazards models were employed to compare tuberculosis incidence risk between diabetes and non-diabetes patients, adjusting for age, gender, and other factors. Additionally, the incidence of tuberculosis was compared between groups with good and poor blood glucose control. Results: During the 6-year follow-up, 79 cases of active tuberculosis were identified, yielding an incidence density of 25.6 (95% CI: 20.4 to 31.7) per 100 000 person-years. In a group of 79 patients, diabetes accounted for 21.5% (17/79), with an incidence density of tuberculosis at 58.8 (95% CI: 35.4 to 92.2) per 100 000 person-years. Non-diabetic patients accounted for 78.5% (62/79), with an incidence density of tuberculosis at 22.1 (95% CI: 17.1 to 28.2) per 100 000 person- years. In the well-controlled blood glucose group, the incidence density of active tuberculosis was 29.6 (95% CI: 21.4 to 33.1) per 100 000 person-years, while in the poorly controlled blood glucose group, the incidence density of active tuberculosis was 63.5 (95% CI: 39.3 to 96.8) per 100 000 person-years. The risk of tuberculosis in diabetes patients was 3.057 times higher than that in the general population (HR=3.057, 95% CI: 1.770 to 5.281, P < 0.001) . The risk of tuberculosis was 3.766 times higher in the group with poor blood glucose control than in the group with good blood glucose control (HR=3.766, 95% CI: 2.054 to 6.906, P < 0.001) . Conclusion: This large - scale cohort study demonstrates that diabetes patients with poor blood glucose control have an increased risk of tuberculosis. Enhanced screening of diabetes patients with poor blood glucose control may facilitate early detection of tuberculosis, potentially reducing its incidence and prevalence in China. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): |
目的: 探讨血糖控制对结核病发病风险的影响。方法: 在江苏省南京市对 60 283例受试者进行为期 6 年的队列研 究, 在排除了基线筛查时发现的活动性结核病患者后, 将受试者与南京市结核病患者管理信息进行匹配以发现活动性结核病 患者。采用 Cox 比例风险模型, 调整年龄、性别等因素后比较糖尿病患者与非糖尿病患者的结核病发病风险, 并比较糖尿病患 者血糖控制良好组与血糖控制不佳组结核病发病的差异。结果: 在 6 年的随访中, 共发现活动性结核病患者 79 例, 发病密度为 25.6 (95%CI: 20.4~31.7) /10万人年。在 79 例患者中, 糖尿病占 21.5% (17/79), 结核发病密度为 58.8 (95%CI: 35.4~92.2) /10万人 年。非糖尿病患者占 78.5% (62/79), 结核发病密度为 22.1 (95%CI: 17.1~28.2) /10 万人年。血糖控制良好组活动性结核病发病 密度为 29.6 (95%CI: 21.4~33.1) /10 万人年, 血糖控制不佳组活动性结核病发病密度为63.5 (95%CI: 39.3~96.8) /10 万人年。糖 尿病患者发生结核病的风险是一般人群的 3.057 倍 (HR=3.057, 95%CI: 1.770~5.281, P < 0.001); 血糖控制不佳组发生结核病的 风险是血糖控制良好组的 3.766 倍 (HR=3.766, 95%CI: 2.054~6.906, P < 0.001) 。结论: 大规模人群队列研究表明, 血糖控制不 佳的糖尿病患者患结核病的风险增加, 因此, 加强对血糖控制不佳的糖尿病患者进行筛查, 可以及早发现结核病, 有助于降低 中国结核病的发病率和流行程度。 [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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