التفاصيل البيبلوغرافية
| العنوان: |
Molecular Photoswitching Unlocks Glucose Oxidase for Synergistically Reinforcing Fenton Reactions for Antitumor Chemodynamic Therapy. |
| المؤلفون: |
Wang, Zicheng1 (AUTHOR), Bao, Weier1 (AUTHOR), Wujieti, Baerlike1 (AUTHOR), Liu, Ming1 (AUTHOR), Li, Xiaojuan1 (AUTHOR), Ma, Zhecheng1 (AUTHOR), Cui, Wei1 (AUTHOR) cuiwei@ucas.ac.cn, Tian, Zhiyuan1 (AUTHOR) zytian@ucas.ac.cn |
| المصدر: |
Angewandte Chemie. 1/2/2025, Vol. 137 Issue 1, p1-9. 9p. |
| مصطلحات موضوعية: |
*GLUCOSE oxidase, *OXIDATION of glucose, *GLUCONIC acid, *HYDROXYL group, *OXIDATIVE stress |
| مستخلص: |
We have developed a new type of nanoparticles with potent antitumor activity photoactivatable via the combination of molecular photoswitching of spiropyran (SP) and enzymatic reaction of glucose oxidase (GOx). As two key processes involved therein, Fe(III)‐to‐Fe(II) photoreduction in Fe(III) metal–organic frameworks (MOFs) brings about the release of free Fe2+/Fe3+ while the photoswitching of SP to merocyanine (MC) unlocks the enzymatic activity of GOx that was pre‐passivated by SP. The release of free Fe3+ boosts its hydrolysis and therefore enables the acidification of microenvironment, which is further reinforced by one of the products of the GOx‐mediated glucose oxidation reaction, gluconic acid (GlcA). Based on the generation of Fe2+ and acidic milieu together with another product of the oxidation reaction, hydrogen peroxide (H2O2), these two processes jointly present triple enabling factors for generating lethal hydroxyl radicals (⋅OH) species via Fenton reactions and therefore oxidative stress capable of inhibiting tumor. The antitumor potency of such nanoparticle is verified in tumor‐bearing model mice in vivo, proclaiming its potential as a potent and safe agent based on the unique mechanism of optically manipulating enzyme activity for synergistic antitumor therapeutics with high spatial precision, enhanced efficacy and minimized side effects. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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