التفاصيل البيبلوغرافية
| العنوان: |
Equilibrium solubility and mathematical modelling of glibenclamide in cosolvent mixtures of glycols and alcohols. |
| المؤلفون: |
Nouri, Leila1,2 (AUTHOR), Rahimpour, Elaheh2,3 (AUTHOR) Rahimpour_e@yahoo.com, Jouyban, Abolghasem2,4 (AUTHOR) |
| المصدر: |
Physics & Chemistry of Liquids. Jan2025, Vol. 63 Issue 1, p108-117. 10p. |
| مصطلحات موضوعية: |
*METHOXYETHANOL, *HYPERGLYCEMIA, *BINARY mixtures, *DRUG solubility, *ATMOSPHERIC pressure |
| مستخلص: |
Glibenclamide (GBN) is a commonly used oral medication for treating type-II diabetes that acts by reducing high blood sugar levels. The effectiveness of GBN depends on the quality of the product. The quality is influenced by the solubility properties of a drug. This study aimed to measure the solubility of GBN in various solvent mixtures including some glycols and alcohols. The solubility was determined using a shake-flask method at 298.2 K under atmospheric pressure. The results showed that GBN had the highest solubility in ethylene glycol monomethyl ether and alcohol mixtures compared to the other tested glycols. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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