التفاصيل البيبلوغرافية
| العنوان: |
Factors associated with oxidative stress in virologically suppressed people living with HIV on long-term antiretroviral therapy. |
| المؤلفون: |
Lombardi, Francesca1,2,3 (AUTHOR) francesca.lombardi@gmail.com, Belmonti, Simone1 (AUTHOR), Sanfilippo, Alessia2 (AUTHOR), Borghetti, Alberto4 (AUTHOR), Iannone, Valentina2 (AUTHOR), Salvo, Pierluigi Francesco2 (AUTHOR), Fabbiani, Massimiliano4,5 (AUTHOR), Visconti, Elena1 (AUTHOR), Giambenedetto, Simona Di1,2 (AUTHOR) |
| المصدر: |
AIDS Research & Therapy. 12/30/2024, Vol. 21 Issue 1, p1-11. 11p. |
| مصطلحات موضوعية: |
*THERAPEUTIC use of antioxidants, *RNA analysis, *ANTIOXIDANT analysis, *RISK assessment, *CROSS-sectional method, *REFERENCE values, *HIGH density lipoproteins, *COMBINATION drug therapy, *ANTIRETROVIRAL agents, *VIRAL load, *RESEARCH funding, *HIV-positive persons, *SEX distribution, *HIV infections, *OXIDATIVE stress, *METABOLITES, *OXIDIZING agents, *PROTEASE inhibitors, *CONFIDENCE intervals, *HEPATITIS C, *REGRESSION analysis, *MIXED infections |
| مستخلص: |
Background: Oxidative stress (OS) is the imbalance between oxidant and antioxidant molecules, in favour of oxidants, that has been associated with an increased risk of morbidity and mortality in ART-treated people living with HIV (PLWH). We aimed to assess factors associated with OS in virologically suppressed PLWH on long-term modern ART. Method: In this cross-sectional study we evaluated OS by measuring both the levels of derivatives-reactive oxygen metabolites (d-ROMs) and the biological antioxidant potential (BAP). We also calculated the BAP/d-ROMs ratio, (OS index, OSi); a cut-off value < 7.3 indicated OS. Factors associated with OS markers were explored by linear regression model. Results: We enrolled 299 experienced PLWH with virological suppression (HIV-RNA < 50cps/mL). The mean of the d-ROMs levels was 409 UCARR (95%CI 394–422), whereas the mean of the BAP levels was 1.809 µmol/L (95%CI 1706–1851). The OSi mean value was 4.84, and 91.6% of the participants were below the cut-off value. By regression analysis, higher production of oxidants was associated with female sex (p < 0.001), current exposition to PIs (p = 0.030) and HCV co-infection (p = 0.006). Higher antioxidant capacity was correlated with higher HDL levels (p = 0.001). A lower OSi was associated with female sex (p = 0.003) and the current use of triple vs. dual regimen (p = 0.036). The OSi correlated negatively with cholesterol levels (p = 0.002) and positively with HDL (p < 0.001). Conclusions: Virologically suppressed PLWH on long-term ART showed a marked OS. Female sex, the exposure to PIs, and HCV co-infection were associated with higher oxidants, while higher HDL levels were linked to better antioxidant capacity. Interestingly, dual therapy, especially INSTI-based regimens, was associated with lower oxidative stress compared to triple therapy. [ABSTRACT FROM AUTHOR] |
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