التفاصيل البيبلوغرافية
| العنوان: |
Bridging the species divide: The limits of rat models in capturing human PVOD mechanisms. |
| المؤلفون: |
Perros, Frédéric1 (AUTHOR) frederic.perros@inserm.fr, Chaveroux, Cédric2 (AUTHOR), Montani, David3 (AUTHOR) |
| المصدر: |
Pulmonary Circulation. Oct2024, Vol. 14 Issue 4, p1-3. 3p. |
| مصطلحات موضوعية: |
*BONE morphogenetic protein receptors, *LABORATORY rats, *RIGHT ventricular hypertrophy, *TRANSCRIPTION factors, PULMONARY artery diseases |
| مستخلص: |
The article discusses the limitations of using rat models to study human pulmonary veno-occlusive disease (PVOD) mechanisms. While rat models have shown promising results in targeting the PKR-ISR axis to manage PVOD, human cases may not exhibit the same activation of this pathway. The study highlights the importance of considering species-specific differences in disease mechanisms and suggests that alternative pathways, such as GCN2 and the BMPR2-SMAD axis, may be more critical in human PVOD. The findings underscore the need for improved in vivo models that better mimic human disease to develop effective therapeutic interventions. [Extracted from the article] |
| قاعدة البيانات: |
Academic Search Index |
Full Text Finder