التفاصيل البيبلوغرافية
| العنوان: |
The role of transforming growth factor β in cervical carcinogenesis. |
| المؤلفون: |
Trugilo, Kleber Paiva1 (AUTHOR) klebertrugilo01@gmail.com, Cebinelli, Guilherme Cesar Martelossi2 (AUTHOR) cebinelli.gcm@gmail.com, Castilha, Eliza Pizarro1 (AUTHOR) eliza.pizarro.castilha@uel.br, da Silva, Mariane Ricciardi1 (AUTHOR) mariane.ricciardi@uel.br, Berti, Fernanda Costa Brandão3 (AUTHOR) fernanda.berti@pelepequenoprincipe.org.br, de Oliveira, Karen Brajão1 (AUTHOR) karen.brajao@uel.br |
| المصدر: |
Cytokine & Growth Factor Reviews. Dec2024, Vol. 80, p12-23. 12p. |
| مصطلحات موضوعية: |
*TRANSFORMING growth factors, *TRANSFORMING growth factors-beta, *HUMAN papillomavirus, *EPITHELIAL-mesenchymal transition, *INHIBITION of cellular proliferation |
| مستخلص: |
Human papillomavirus (HPV) is involved in virtually all cases of cervical cancer. However, HPV alone is not sufficient to cause malignant development. The effects of chronic inflammation and the interaction of immune components with the microenvironment infected with the high-risk HPV type (HR) may contribute to cancer development. Transforming growth factor β (TGFB) appears to play an important role in cervical carcinogenesis. Protein and mRNA levels of this cytokine gradually increase as normal tissue develops into malignant tissue and are closely related to the severity of HPV infection. At the onset of infection, TGFB can inhibit the proliferation of infected cells and viral amplification by inhibiting cell growth and downregulating the transcriptional activity of the long control region (LCR) of HPV, thereby reducing the expression of early genes. When infected cells progress to a malignant phenotype, the response to the cell growth inhibitory effect of TGFB1 is lost and the suppression of E6 and E7 expression decreases. Subsequently, TGFB1 expression is upregulated by high levels of E6 and E7 oncoproteins, leading to an increase in TGFB1 in the tumor microenvironment, where this molecule promotes epithelial-to-mesenchymal transition (EMT), cell motility, angiogenesis, and immunosuppression. This interaction between HPV oncoproteins and TGFB1 is an important mechanism promoting the development and progression of cervical cancer. [Display omitted] • TGFB1 has a suppressor role at the early stages of HPV infection. • Once the cells become malignant, their response to TGFB1 decreases. • Without TGFB1 suppression, oncoproteins E6 and E7 are increasingly expressed. • Increased E6 and E7 can upregulate TGFB1 in the tumor microenvironment. • Cytokines interactions are key to the promotion and progression of cervical cancer. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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