التفاصيل البيبلوغرافية
| العنوان: |
Melatonin Attenuates Imiquimod-Induced Psoriasis-Like Inflammation and Restores the Th17/Treg Immune Balance. |
| المؤلفون: |
Shen, Zhanting1,2 (AUTHOR), Jiang, Jinqiu1,2 (AUTHOR), Zhou, Xiaoying1,2 (AUTHOR), Tan, Qingqing1,2 (AUTHOR), Yan, Shi2 (AUTHOR), Wu, Xuege2 (AUTHOR), Pi, Jiangshan1,2 (AUTHOR), Wang, Hua1,2 (AUTHOR), Yang, Huan1,2 (AUTHOR), Luo, Xiaoyan1,2 (AUTHOR) xyluo@hospital.cqmu.edu.cn |
| المصدر: |
Inflammation. Dec2024, Vol. 47 Issue 6, p2027-2040. 14p. |
| مصطلحات موضوعية: |
*SKIN inflammation, *PROTEOMICS, *REGULATORY T cells, *SKIN diseases, *INFLAMMATION |
| مستخلص: |
Psoriasis is a common immune-mediated skin disease characterized by abnormally reactive inflammation and epidermal hyperplasia. Previous studies have shown melatonin (MLT) has powerful anti-inflammatory effects. The mechanisms that MLT regulates psoriasis-associated skin inflammation remain unclear. Here, in imiquimod-induced psoriasis-like mice, MLT supplementation reduced skin inflammation and corrected the Th17/Treg cell imbalance. Network pharmacology and proteome sequencing analyses revealed that MLT attenuates the inflammatory response in the skin of psoriatic mice by inhibiting the PI3K/Akt signaling pathway. Overall, the data suggest that MLT has a protective effect against psoriasis-like inflammation. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |