التفاصيل البيبلوغرافية
| العنوان: |
Effective synergism of Moringa oleifera with antibiotics, body growth, and decoction replacement. |
| المؤلفون: |
Ashraf, Qandeel1 (AUTHOR), Aqib, Amjad Islam1,2 (AUTHOR) amjadislamaqib@cuvas.edu.pk, Majeed, Hamid1 (AUTHOR), Haq, Shahbaz Ul3 (AUTHOR), Nisar, Muhammad Farrukh4,5 (AUTHOR), Usman, Muhammad6 (AUTHOR), Muneer, Afshan7 (AUTHOR), Batool, Saba7 (AUTHOR), Ataya, Farid S.8 (AUTHOR) |
| المصدر: |
South African Journal of Botany. Dec2024, Vol. 175, p628-636. 9p. |
| مصطلحات موضوعية: |
*PHYTOCHEMICALS, *HIGH performance liquid chromatography, *MORINGA oleifera, *ANTIBACTERIAL agents, *KLEBSIELLA pneumoniae, *GREEN tea, *SAPONINS, *FLAVONOID glycosides |
| مستخلص: |
• Moringa contains significant phytochemical profile. • Antibacterial synergism with antibiotics is appreciable. • Decoction is replaceable with green tea. • Public acceptability was appreciable. The increasing trend in antibiotic resistance and food safety demands exploring nutraceutical products for optimized health. The current study explores the synergism of Moringa oleifera extracts (MOE) with antibiotics, body growth, and public acceptance as a decoction for better health. Plants collected from the South Punjab province of Pakistan were subjected to extraction through reflux extraction and characterized using HPLC (high-performance liquid chromatography). Phytochemical analysis revealed enriched contents of reducing sugars, alkaloids, saponins, flavonoids, saponins, tannins, glycosides, and steroids, all of which possess significant antioxidant potential. The antibacterial activity of MOE showed the highest zones of inhibitions against Klebsiella pneumoniae, followed by Escherichia coli and Staphylococcus aureus. There was a significant reduction in the minimum inhibitory concentration (MIC) of the antibiotics when used in combination with MOE against bacteria. None of the combinations exhibited antagonistic effects. Feeding MOE led to significant improvements in growth and weight of the mice, while histopathological parameters were significantly higher among all, except for glomerular diameter, sinusoid width, and corpuscle density. The decoction trial showed the highest odd ratio for the acceptability within a preparation having higher proporotion of MOE. The study thus revealed the enriched nutraceutical contents in MO extracts, their potential for synergism with antibiotics, optimized growth effects, and significant public acceptance. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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