التفاصيل البيبلوغرافية
| العنوان: |
Recurrent Early Pregnancy Loss and Congenital Thrombophilia: A Prospective Study. |
| المؤلفون: |
Basha, Asma1,2 (AUTHOR) a.basha@ju.edu.jo, Alkhatib, Yasmine2 (AUTHOR) tamara_tashtoush_90@hotmail.com, Tashtoush, Tamara2 (AUTHOR), Yousef, Maysa2 (AUTHOR), Oweidi, Laila3 (AUTHOR) m_alkhatib2004@yahoo.com, Alkhatib, Mohammad3 (AUTHOR), Al-Aqrabawi, Sally4 (AUTHOR) sally2ms@gmail.com, Jarrar, Yazun5 (AUTHOR) yazun.jarrar@bau.edu.jo, Awidi, Abdalla3,4 (AUTHOR) aabbadi@ju.edu.jo |
| المصدر: |
Journal of Clinical Medicine. Nov2024, Vol. 13 Issue 22, p6871. 11p. |
| مصطلحات موضوعية: |
*RECURRENT miscarriage, *PROTEIN C, *PARTIAL thromboplastin time, *FACTOR V Leiden, *METHYLENETETRAHYDROFOLATE reductase |
| مستخلص: |
Background/Objectives: This study aims to investigate the role of congenital single nucleotide thrombophilia in young females with early recurrent pregnancy loss (RPL). Methods: We studied 120 pregnant females with RPL and 80 matched females as a control with no RPL. Females were aged ≤ 35 years, had at least two consecutive first-trimester RPLs, and the acquired cause of RPL was excluded. A matched control group of 80 pregnant women with no RPL was studied. Coagulation tests included prothrombin time (PT), partial thromboplastin time (PTT), thrombin time (TT), a Factor XIII functional assay, and detecting IgM and IgG anti-beta2-Glycoprotein I (β2GPI) antibodies by an ELISA. The DNA samples were tested for Factor V Leiden, Factor II G20210A, Methylenetetrahydrofolate reductase (MTHFR C677T, A1298C), FXIII V34L, plasminogen activator inhibitor-1 (PAI-1) 4G/5G, endothelial protein C receptor (EPCR) A4600G, and endothelial protein C receptor (EPCR) G4678C. Results: Of the single nucleotide gene mutations investigated, the most relevant mutations were MTHFR C677T, MTHFR A1298C, heterozygous FXIII Val34Leu, and heterozygous FXIII 1694 C>T. Each of them conferred a statistically significant effect. There was a statistically significant protective role for the endothelial protein C receptor (EPCR) A2/A2, wild FXIII Val34Leu, and heterozygousFXIII1694 C>T. Conclusions: Our findings suggest the important role of congenital single nucleotide thrombophilia mutations in young Middle Eastern women with early RPL, particularly MTHFR mutations and FXIII Val34Leu. We found a protective effect of EPCR A2/A2, wild FXIIIVal34Leu, and heterozygous FXIII1694 C>T. We recommend additional studies to explore detrimental factors and protective factors. [ABSTRACT FROM AUTHOR] |
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