التفاصيل البيبلوغرافية
| العنوان: |
Oxidized Phospholipids and Calcific Aortic Valvular Disease. |
| المؤلفون: |
Bhatia, Harpreet S.1 (AUTHOR), Dweck, Marc R.2 (AUTHOR), Craig, Neil2 (AUTHOR), Capoulade, Romain3 (AUTHOR), Pibarot, Philippe4 (AUTHOR), Trainor, Patrick J.5 (AUTHOR), Whelton, Seamus P.6 (AUTHOR), Rikhi, Rishi7 (AUTHOR), Lidani, Karita C.F.8 (AUTHOR), Post, Wendy S.6 (AUTHOR), Tsai, Michael Y.9 (AUTHOR), Criqui, Michael H.1,10 (AUTHOR), Shapiro, Michael D.7 (AUTHOR), Budoff, Matthew J.11 (AUTHOR), DeFilippis, Andrew P.8 (AUTHOR), Thanassoulis, George12 (AUTHOR), Tsimikas, Sotirios1 (AUTHOR) |
| المصدر: |
Journal of the American College of Cardiology (JACC). Dec2024, Vol. 84 Issue 25, p2430-2441. 12p. |
| مصطلحات موضوعية: |
*AORTIC valve diseases, *AORTIC valve, *AORTIC stenosis, *HEART valve diseases, *PHOSPHOLIPIDS |
| مستخلص: |
Oxidized phospholipids (OxPLs) are carried by apolipoprotein B-100–containing lipoproteins (OxPL-apoB) including lipoprotein(a) (Lp[a]). Both OxPL-apoB and Lp(a) have been associated with calcific aortic valve disease (CAVD). This study aimed to evaluate the associations between OxPL-apoB, Lp(a) and the prevalence, incidence, and progression of CAVD. OxPL-apoB and Lp(a) were evaluated in MESA (Multi-Ethnic Study of Atherosclerosis) and a participant-level meta-analysis of 4 randomized trials of participants with established aortic stenosis (AS). In MESA, the association of OxPL-apoB and Lp(a) with aortic valve calcium (AVC) at baseline and 9.5 years was evaluated using multivariable ordinal regression models. In the meta-analysis, the association between OxPL-apoB and Lp(a) with AS progression (annualized change in peak aortic valve jet velocity) was evaluated using multivariable linear regression models. In MESA, both OxPL-apoB and Lp(a) were associated with prevalent AVC (OR per SD: 1.19 [95% CI: 1.07-1.32] and 1.13 [95% CI: 1.01-1.27], respectively) with a significant interaction between the two (P < 0.01). Both OxPL-apoB and Lp(a) were associated with incident AVC at 9.5 years when evaluated individually (interaction P < 0.01). The OxPL-apoB∗Lp(a) interaction demonstrated higher odds of prevalent and incident AVC for OxPL-apoB with increasing Lp(a) levels. In the meta-analysis, when analyzed separately, both OxPL-apoB and Lp(a) were associated with faster increase in peak aortic valve jet velocity, but when evaluated together, only OxPL-apoB remained significant (ß: 0.07; 95% CI: 0.01-0.12). OxPL-apoB is a predictor of the presence, incidence, and progression of AVC and established AS, particularly in the setting of elevated Lp(a) levels, and may represent a novel therapeutic target for CAVD. [Display omitted] [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |