التفاصيل البيبلوغرافية
| العنوان: |
Orbitofrontal cortex hypergyrification in hallucinating schizophrenia patients: Surface ratio as a promising brain biomarker. |
| المؤلفون: |
Núñez, Christian1 (AUTHOR), Stephan-Otto, Christian1,2,3,4 (AUTHOR), Roldán, Alexandra1,3,5 (AUTHOR) aroldanb@santpau.cat, Grasa, Eva Mª1,3 (AUTHOR), Escartí, Mª José3,6,7,8 (AUTHOR), Aguilar García-Iturrospe, Eduardo J.3,6,7,8 (AUTHOR), García-Martí, Gracián3,9 (AUTHOR), de la Iglesia-Vaya, Maria3,10 (AUTHOR), Nacher, Juan3,7,11 (AUTHOR), Portella, Maria J.1,3,12 (AUTHOR), Corripio, Iluminada1,3,13,14 (AUTHOR) |
| المصدر: |
European Neuropsychopharmacology. Dec2024, Vol. 89, p47-55. 9p. |
| مصطلحات موضوعية: |
*AUDITORY hallucinations, *PREFRONTAL cortex, *MAGNETIC resonance imaging, *PEOPLE with schizophrenia, *BRAIN anatomy |
| مستخلص: |
The study of brain gyrification may provide useful information on the cytoarchitecture and connectivity of the brain. One of the methods that have been developed to estimate brain gyrification, known as surface ratio (SR), has not yet been studied in schizophrenia. Here we aimed to assess whether SR could provide new insights on the brain structure of schizophrenia patients and the severity of symptoms. We also computed a more established brain gyrification measure, namely absolute mean curvature (AMC). We analyzed 63 magnetic resonance images, 25 from schizophrenia patients with treatment-resistant auditory verbal hallucinations (SCH-H), 18 from schizophrenia patients without hallucinations (SCH-NH), and 20 from healthy controls (HC). The SR measure revealed that SCH-H patients had a more folded orbitofrontal cortex than SCH-NH patients and HC. Gyrification in this region was also negatively associated with positive symptoms, specifically with the delusions and conceptual disorganization items, only in the SCH-H group. Regarding the AMC measure, we identified two areas where HC showed more gyrification than SCH-H patients, but no relationships arose with symptoms. The hypergyrification of the orbitofrontal cortex displayed by SCH-H patients, as captured by the SR measure, suggests aberrant and/or excessive wiring in these patients, which in turn could give rise to auditory verbal hallucinations. Alternatively, we comment on potential compensatory mechanisms that may better explain the negative association between orbitofrontal gyrification and positive symptomatology. The SR measure captured the most relevant differences and associations, making it a promising biomarker in schizophrenia. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |