التفاصيل البيبلوغرافية
| العنوان: |
Asymmetric Intermolecular Conjugate Addition of 3-Substituted 2-Benzofuranones to Maleimides via Noncovalent NHC Catalysis. |
| المؤلفون: |
Mondal, Bhaskar Deb1 (AUTHOR), Gorai, Sadhan1 (AUTHOR), Guin, Joyram1 (AUTHOR) ocjg@iacs.res.in |
| المصدر: |
Synlett. Dec2024, Vol. 35 Issue 20, p2453-2458. 6p. |
| مصطلحات موضوعية: |
*CONJUGATE addition reactions, *MALEIMIDES, *BIOCHEMICAL substrates, *CATALYSIS, *CARBENES |
| مستخلص: |
An efficient N-heterocyclic carbene (NHC)-catalyzed asymmetric conjugate addition reaction to afford synthetically challenging benzofuranone derivatives having vicinal all-carbon quaternary and tertiary stereocenters is presented. The reaction operates solely through noncovalent interaction between a newly designed NHC and the substrates, providing access to a series of functionalized benzofuranones in good yields and with high ee values. The protocol applies to preparative-scale synthesis. A catalytic cycle involving a noncovalent substrate–NHC interaction is implicated in the process, based on a mechanistic control study. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |