التفاصيل البيبلوغرافية
| العنوان: |
Sex differences in the role of AKAP12 in behavioral function of middle-aged mice. |
| المؤلفون: |
Ishikawa, Hidehiro1,2 (AUTHOR), Kimura, Shintaro1,3 (AUTHOR), Takase, Hajime1,4 (AUTHOR), Borlongan, Maximillian1 (AUTHOR), Fukuda, Norito1 (AUTHOR), Hoshino, Tomonori1 (AUTHOR), Hamanaka, Gen1 (AUTHOR), Park, Ji Hyun1 (AUTHOR), Shindo, Akihiro2 (AUTHOR), Kim, Kyu-Won5 (AUTHOR), Gelman, Irwin H.6 (AUTHOR), Lok, Josephine1,7 (AUTHOR), Lo, Eng H.1 (AUTHOR), Arai, Ken1 (AUTHOR) karai@partners.org |
| المصدر: |
Biology of Sex Differences. 11/21/2024, Vol. 15 Issue 1, p1-12. 12p. |
| مصطلحات موضوعية: |
*CURIOSITY, *SHORT-term memory, *SCAFFOLD proteins, *CELL communication, *KNOCKOUT mice |
| Abstract (English): |
A-kinase anchoring protein 12 (AKAP12) is a key scaffolding protein that regulates cellular signaling by anchoring protein kinase A (PKA) and other signaling molecules. While recent studies suggest an important role for AKAP12 in the brain, including cognitive functions, its role in middle-aged mice and potential sex differences are not fully understood. Therefore, this study investigated the effects of AKAP12 on cognitive and exploratory behavior in middle-aged mice, focusing on sex differences. Cognitive function was assessed using the spontaneous Y-maze test and the novel object recognition test (NORT). No significant sex differences in cognitive function were found in middle-aged C57BL/6J mice; however, female mice showed greater exploratory behavior during the NORT. In addition, both middle-aged male and female Akap12 knockout (KO) mice performed similarly to wild-type (WT) mice in the Y-maze test, but had lower discrimination indices in the NORT, suggesting a potential role for AKAP12 in short-term memory. Notably, exploratory behavior was suppressed in female Akap12 KO mice compared to WT mice, whereas male Akap12 KO mice did not show this effect. There were no significant differences in movement distance and velocity during the Y-maze test and NORT between WT and KO mice of either sex. These results indicate that AKAP12 affects cognitive function and exploratory behavior in middle-aged mice and that these effects differ between sexes. Highlights: This study examines the role of A-kinase anchoring protein 12 (AKAP12) in cognitive and exploratory behavior, focusing on sex-related differences in middle-aged mice. Our results show that AKAP12 deficiency impairs short-term memory in both sexes, but specifically reduces exploratory behavior in female mice, highlighting a potential sex-specific role of AKAP12 in regulating exploratory behavior. Given the growing interest in understanding the molecular and cellular mechanisms underlying brain function and behavior, particularly in the context of sex differences, our findings will provide valuable insights into the field of neuroscience. [ABSTRACT FROM AUTHOR] |
| Abstract (French): |
Plain English Summary: This study examines how a protein called A-kinase anchoring protein 12 (AKAP12) affects memory and behavior in middle-aged mice, and whether it works differently in males and females. AKAP12 is known to regulate important brain functions, but its role in potential sex differences hasn't been fully explored. In this study, we tested the memory and exploratory behavior of the mice. Both male and female mice performed similarly in memory tests, but female mice explored objects more than males. When AKAP12 was removed from the brains of the middle-aged mice, both males and females showed memory problems, but only females had reduced exploratory behavior. Our results suggest that AKAP12 is important for memory maintenance and influences behavior in middle-aged mice. In addition, the differences we observed between males and females highlight the potential of AKAP12 as a target for treatments aimed at memory and cognitive problems, especially as people age or develop brain-related diseases. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
Full Text Finder