التفاصيل البيبلوغرافية
| العنوان: |
血清 25-(OH)D3, sVCAM-1, MMP-9 与慢性乙型肝炎病毒感染孕妇 合并妊娠期肝内胆汁淤积症的关系研究. |
| Alternate Title: |
Study on the Relationship between Serum 25-(OH)D3, sVCAM-1, MMP-9 and Intrahepatic Cholestasis of Pregnancy in Pregnant Women with Chronic Hepatitis B Virus Infection. |
| المؤلفون: |
杨天卓1 tianzhuoyang2016@163.com, 李艳丽2, 王 俊1, 李 好3, 欧阳夕颜1, 高 晗2 gaohan@hbfy.com |
| المصدر: |
Progress in Modern Biomedicine. Oct2024, Vol. 24 Issue 20, p3987-3989. 3p. |
| مصطلحات موضوعية: |
*VASCULAR cell adhesion molecule-1, *CHRONIC hepatitis B, *VIRUS diseases, *PREGNANT women, *LOGISTIC regression analysis |
| Abstract (English): |
Objective: To investigate the relationship between serum 25-hydroxyvitamin D3 [25- (OH)D3], soluble vascular cell adhesion molecule-1 (sVCAM-1), matrix metalloproteinase-9 (MMP-9) and intrahepatic cholestasis of pregnancy (ICP) in pregnant women with chronic hepatitis B (CHB) virus infection. Methods: 120 pregnant women with CHB virus infection with ICP admitted to the Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology from January 2021 to December 2023 were selected as the study subjects (combined group), and 100 pregnant women with CHB virus infection without ICP were selected as control (non-combined group), the levels of serum 25- (OH)D3, SVCAM-1 and MMP-9 were compared between two groups. The related factors of ICP were analyzed by univariate and multivariate Logistic regression analysis. Results: The levels of serum sVCAM-1 and MMP-9 in combined group were higher than those in non-combined group (P<0.05), and 25- (OH)D3 was lower than that in non-combined group (P<0.05). Multivariate Logistic regression analysis showed that, elevated serum SVCAM-1 and MMP-9 were risk factors for ICP in pregnant women with CHB virus infection, and elevated 25-(OH)D3 was a protective factor for ICP in pregnant women with CHB virus infection (all P<0.05). Conclusion: Serum 25- (OH)D3, sVCAM-1 and MMP-9 in pregnant women with CHB virus infection are closely relate to the occurrence of ICP. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): |
探讨血清 25- 羟维生素 D3[25-(OH)D3]、可溶性血管细胞黏附分子 -1 (sVCAM-1) 、基质金属蛋白酶 -9 (MMP-9) 与慢性 乙型肝炎 (CHB) 病毒感染孕妇合并妊娠期肝内胆汁淤积症 (ICP) 的关系。方法：选择 2021 年 1 月至 2023 年 12 月华中科技大学 同济医学院附属湖北妇幼保健院收治的的 120 例 CHB 病毒感染合并 ICP 孕妇作为研究对象 (合并组), 以未合并 ICP 的 100 例 CHB 病毒感染孕妇作为对照 (未合并组) 。比较两组血清 25-(OH)D3、sVCAM-1、MMP-9 水平。单因素和多因素 Logistic 回归分析 发生 ICP 的相关因素。结果：合并组孕妇血清 sVCAM-1、MMP-9 均高于未合并组 (P<0.05), 25-(OH)D3 低于未合并组 (P<0.05) 。多 因素 Logistic 回归分析结果显示，血清 sVCAM-1 和 MMP-9 升高是 CHB 病毒感染孕妇合并 ICP 的危险因素，25-(OH)D3 升高是 CHB 病毒感染孕妇合并 ICP 的保护因素 (P 均 <0.05) 。结论：CHB 病毒感染孕妇血清 25-(OH)D3、sVCAM-1、MMP-9 与 ICP 的发 生密切相关。 [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |