التفاصيل البيبلوغرافية
| العنوان: |
细菌性血流感染所致脓毒症患者中性粒细胞 CD64 指数 联合血清 APOM、HMGB1 对预后的评估价值. |
| Alternate Title: |
Evaluation Value of Prognosis of Neutrophil CD64 Index Combined with Serum APOM and HMGB1 in Patients with Sepsis Caused by Bacterial Bloodstream Infection. |
| المؤلفون: |
张 祎1 jiaodajyk@163.com, 徐 倩2, 仝晓宁1, 张 晶1, 王文静3 wangwenjing@xjtu.edu.cn |
| المصدر: |
Progress in Modern Biomedicine. Oct2024, Vol. 24 Issue 20, p3967-3970. 4p. |
| مصطلحات موضوعية: |
*HIGH mobility group proteins, *BACTERIAL diseases, *RECEIVER operating characteristic curves, *C-reactive protein, *LOGISTIC regression analysis |
| Abstract (English): |
Objective: To study the evaluation value of prognosis of neutrophil CD64 index combined with serum apolipoprotein M (APOM) and high mobility group protein B1 (HMGB1) in patients with sepsis caused by bacterial bloodstream infection. Methods: 251 patients with sepsis caused by bacterial bloodstream infection were divided into survival group and death group according to whether they experienced mortality after 28 days of admission. The influencing factors of 28 d mortality were analyzed by Logistic regression model, the value of CD64 index, serum APOM, HMGB1 and conventional infection indicators in predicting 28 d mortality in patients with sepsis caused by bacterial bloodstream infection were analyzed by receiver operating characteristic (ROC) curve. Results: Compared with survival group, the neutrophil CD64 index and HMGB1 in death group were significantly increased, and the serum APOM was significantly decreased (P<0.05). High APACHEII score, high procalcitonin, high neutrophil CD64 index, high C-reactive protein, high HMGB1, and low APOM were risk factors for 28 d mortality in patients with sepsis caused by bacterial bloodstream infection (P<0.05). ROC curve showed that, the area under the curve (AUC) of procalcitonin, C-reactive protein, neutrophil CD64 index, APOM and HMGB1 in predicting the 28 d mortality risk of sepsis patients caused by bacterial bloodstream infection was 0.917, which was greater than that predicted by single index. Conclusion: The increase of neutrophil CD64 index, HMGB1 and the decrease of APOM are related to the risk of 28 d mortality in patients with sepsis caused by bacterial bloodstream infection, and combined with procalcitonin and C-reactive protein has a high predictive value. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): |
目的: 研究细菌性血流感染所致脓毒症患者中性粒细胞 CD64 指数联合血清载脂蛋白 M (APOM) 、高迁移率族蛋白 B1 (HMGB1) 对预后的评估价值。方法: 251 例细菌性血流感染所致脓毒症患者, 根据入院 28 d 是否出现了病死分为存活组和病死 组。采用 Logistic 回归模型分析入院 28 d 病死的影响因素, 采用受试者工作特征 (ROC) 曲线分析 CD64 指数、血清 APOM、 HMGB1 与常规感染指标预测患者入院 28 d 病死的价值。结果: 与存活组比较, 病死组中性粒细胞 CD64 指数、HMGB1 显著升 高, 血清 APOM 显著降低 (P＜0.05) 。APACHEⅡ评分高、降钙素原高、中性粒细胞 CD64 指数高、C 反应蛋白高、HMGB1 高、 APOM 低是细菌性血流感染所致脓毒症患者入院 28 d 病死的危险因素 (P＜0.05) 。ROC 曲线显示, 降钙素原、C 反应蛋白、中性粒 细胞 CD64 指数、APOM、HMGB1 联合预测细菌性血流感染所致脓毒症患者入院 28 d 病死风险的曲线下面积 (AUC) 为 0.917, 大 于单项指标预测。结论: 中性粒细胞 CD64 指数、HMGB1 升高及 APOM 降低与细菌性血流感染所致脓毒症患者入院 28 d 病死风 险相关, 且联合降钙素原、C 反应蛋白有较高的预测价值。 [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |