التفاصيل البيبلوغرافية
| العنوان: |
Beyond modular enhancers: new questions in cis-regulatory evolution. |
| المؤلفون: |
McDonald, Jeanne M.C.1 (AUTHOR) jmm836@cornell.edu, Reed, Robert D.1 (AUTHOR) |
| المصدر: |
Trends in Ecology & Evolution. Nov2024, Vol. 39 Issue 11, p1035-1046. 12p. |
| مصطلحات موضوعية: |
*EVOLUTIONARY developmental biology, *EVOLUTIONARY models, *GENE expression, *TRANSCRIPTION factors |
| مستخلص: |
Many studies challenge the view that gene expression is primarily controlled by rapidly evolving, highly specific, and independently acting enhancers. Functional conservation of cis -regulatory elements, and the frequency of their co-option, may be underestimated because cis -regulatory elements can diverge considerably in sequence while binding the same transcription factors and performing the same developmental roles across species. cis -Regulatory elements are often involved in regulating gene expression in the development of multiple traits and can be highly interdependent upon each other. Some cis -regulatory elements are more robust to mutation compared with others, and the fragility of the cis -regulatory architecture of a trait could predict its rate of evolution. New molecular insights prompt us to propose new questions for evolutionary developmental biology. Our understanding of how cis -regulatory elements work has advanced rapidly, outpacing our evolutionary models. In this review, we consider the implications of new mechanistic findings for evolutionary developmental biology. We focus on three different debates: whether evolutionary innovation occurs more often via the modification of old cis -regulatory elements or the emergence of new ones; the extent to which individual elements are specific and autonomous or multifunctional and interdependent; and how the robustness of cis -regulatory architectures influences the rate of trait evolution. These discussions lead us to propose new questions for the evo-devo of cis -regulation. Our understanding of how cis -regulatory elements work has advanced rapidly, outpacing our evolutionary models. In this review, we consider the implications of new mechanistic understandings for evolutionary developmental biology. We focus on three different debates: whether evolutionary innovation occurs more often via the modification of old cis -regulatory elements or the emergence of new ones; the extent to which individual elements are specific and autonomous or multifunctional and interdependent; and how the robustness of cis -regulatory architectures influences the rate of trait evolution. These discussions lead us to propose new questions for the evo-devo of cis -regulation. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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