التفاصيل البيبلوغرافية
| العنوان: |
Evaluating the efficacy of botulinum toxin in treating complex regional pain syndrome: A systematic review. |
| المؤلفون: |
Almeida, Bruno Oliveira1 (AUTHOR), Barreto, Eduardo Silva Reis1 (AUTHOR) eduardosrb@ufba.br, Antunes Júnior, Cesar Romero1 (AUTHOR), Alencar, Vinicius Borges1 (AUTHOR), Souza, Anna Karla do Nascimento1 (AUTHOR), Azi, Liana Maria Torres de Araujo1 (AUTHOR), Lins-Kusterer, Liliane Elze Falcão1 (AUTHOR), Kraychete, Durval Campos1 (AUTHOR) |
| المصدر: |
Toxicon. Nov2024, Vol. 250, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*COMPLEX regional pain syndromes, *NERVE block, *RANGE of motion of joints, *ANALGESIA, *PAIN management, *BOTULINUM toxin, *BOTULINUM A toxins |
| مستخلص: |
Complex Regional Pain Syndrome (CRPS) is characterized by pain, swelling, limited range of motion, skin changes, vasomotor instability, and bone demineralization. This study aims to assess the efficacy of botulinum toxin type A (BoNT-A) in the treatment of CRPS. We conducted a systematic literature review following the PRISMA guidelines, using the PICO strategy (Patient, Intervention, Comparison and Outcome) with the following criteria: P = Patients with CRPS; I = Botulinum toxin; C = Placebo or active drug; and O = Pain relief. Three randomized controlled trials with placebo controls were included, involving a total of 64 patients, 36 of whom received BoNT-A in doses ranging from 40U to 200U. The studies examined both lumbar sympathetic block and local application methods. Botulinum toxin shows promise in alleviating pain associated with CRPS, particularly when used as an adjunct to lumbar sympathetic blockade. However, the limited number of studies and small sample sizes impede reaching definitive conclusions regarding its efficacy and safety. Notably, local applications (intradermal or subcutaneous) require further investigation, as current evidence is insufficient and reports indicate patient discomfort. While preliminary findings suggest potential benefits of BoNT-A in managing CRPS, larger randomized trials are necessary to confirm its efficacy and safety. • Three randomized controlled trials evaluate Botulinum Toxin's efficacy in CRPS treatment. • Botulinum toxin combined with lumbar sympathetic block significantly reduces pain and prolongs analgesia. • Treatment with local application still lacks evidence. • Further research is needed to determine the optimal Botulinum Toxin dosage for sympathetic blocks in CRPS. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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