التفاصيل البيبلوغرافية
| العنوان: |
Enzymatic kinetic resolution of an intermediate alcohol of the drug Tegoprazan using lipase from Thermomyces lanuginosus. |
| المؤلفون: |
Pulivarthi, Deepthi1 (AUTHOR), Patlolla, Ravinder Reddy2,3 (AUTHOR), Kuni, Joshna2 (AUTHOR), Gajjala, Raveena2,3 (AUTHOR), Kethavath, Santhosh Nayak3,4 (AUTHOR), Banoth, Linga2,3 (AUTHOR) Linga@iict.res.in, B V, Subba Reddy1,3 (AUTHOR) |
| المصدر: |
Biocatalysis & Biotransformation. Dec2024, Vol. 42 Issue 6, p653-660. 8p. |
| مصطلحات موضوعية: |
*SUSTAINABLE chemistry, *KINETIC resolution, *ENZYMES, *LIPASES, *ESTERIFICATION |
| مستخلص: |
An enzymatic approach for the synthesis of intermediate alcohol of the drug tegoprazan in 99% ee at 20 °C in hexane has been developed utilizing commercially available immobilized Thermomyces lanuginosus lipase (TL lipase) as a biocatalyst and vinyl acetate as a acyl donor. This method involves the enantioselective esterification of (RS)-5,7-difluorochroman-4-ol with vinyl acetate using TL Lipase. This enzymatic approach provides the (S)-chiral alcohol in 44% yield with 99% enantiomeric excess (ee) and the (R)-acetate in 43% yield and >99% ee. It is a sustainable approach for the synthesis of enantiopure tegoprazan intermediate, contributing to the advancement of green chemistry. The recovered TL lipase was reused in 13 subsequent runs without loss of activity. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |