التفاصيل البيبلوغرافية
| العنوان: |
Serum Levels of Glutathione and Malondialdehyde in Patients with Type 2 Diabetes with Coronary Heart Disease at Khorramabad Heart Hospital, Western Iran: A Cross-Sectional Study. |
| المؤلفون: |
Ahmadi, Babak Baharvand1 bbaharvandahmadi@ymail.com, Esfahani, Reyhaneh Narenjkar2 rnarenikaresfahani@ymail.com |
| المصدر: |
Plant Biotechnology Persa. 2024, Vol. 6 Issue 2, p80-83. 4p. |
| مصطلحات موضوعية: |
*GLUTATHIONE, *MALONDIALDEHYDE, *CORONARY disease, *TYPE 2 diabetes, *OXIDATIVE stress |
| مستخلص: |
Objective: Type 2 diabetes is associated with an increased risk of coronary heart disease (CHD) due to metabolic and oxidative disturbances in the body. Glutathione, a key antioxidant, and malondialdehyde (MDA), an oxidative marker, play crucial roles in evaluating oxidative stress and cellular damage. This study aims to investigate the serum levels of these markers in patients with type 2 diabetes and CHD to better understand the relationship between oxidative stress and cardiovascular disease in this population. Methods: This cross-sectional study was conducted at Khorramabad Heart Hospital in Western Iran, including 100 patients with type 2 diabetes and CHD (T2DM-CHD) over a two-month period. Blood samples were collected from fasting volunteers in the control group for comparison. After centrifugation and serum separation, biochemical assays were performed to measure serum levels of MDA and glutathione. Results: The serum level of MDA in the T2DM-CHD group was measured at 19.3 ± 16.8 µmol/mg protein, significantly higher than the control group (6.9 ± 3.3 µmol/mg protein). Additionally, serum glutathione levels in the diabetic group were 15.3 ± 6.5 µmol/mg protein, notably lower compared to the control group (34.8 ± 10 µ mol/mg protein). Conclusion: The study indicates that patients with type 2 diabetes and CHD exhibit elevated levels of MDA and reduced glutathione, reflecting high oxidative stress. This imbalance may contribute to the progression of diabetes-related complications and cardiovascular diseases. Therefore, the use of antioxidants as medications or supplements could be an effective strategy to reduce oxidative stress and improve clinical outcomes in these patients. Further research is needed to determine the optimal type and dose of antioxidants. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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