التفاصيل البيبلوغرافية
| العنوان: |
Dopaminergic and anti-estrogenic responses in juvenile steelhead (Oncorhynchus mykiss) exposed to bifenthrin. |
| المؤلفون: |
Magnuson, Jason T.1,2 (AUTHOR) jmagnuson@usgs.gov, Sy, Nathan D.2 (AUTHOR), Tanabe, Philip2,3 (AUTHOR), Ji, Chenyang2 (AUTHOR), Gan, Jay2 (AUTHOR), Schlenk, Daniel2 (AUTHOR) |
| المصدر: |
Comparative Biochemistry & Physiology Part C: Toxicology & Pharmacology. Nov2024, Vol. 285, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*BIFENTHRIN, *STEELHEAD trout, *MONOAMINE oxidase, *RAINBOW trout, *PYRETHROIDS, *DOPAMINE receptors, *CATECHOL-O-methyltransferase |
| مستخلص: |
The frequency of detection and concentrations of bifenthrin, a pyrethroid insecticide, in the waterways inhabited by the endangered species, steelhead trout (Oncorhynchus mykiss), has become a significant concern for regulatory agencies. Endocrine disruption has been observed with estrogenic and anti-estrogenic responses in fish species at different life stages. Since several studies have indicated alterations in dopaminergic signaling associated with endocrine responses, juvenile steelhead were exposed to environmentally relevant concentrations of 60 or 120 ng/L bifenthrin for two weeks. Fish brains were assessed for dopamine levels and the expression of genes involved in dopaminergic and estrogenic processes, such as catechol- o -methyltransferase (comt) and monoamine oxidase (mao). Vitellogenin (vtg) and estrogenic receptors (ERα1 , ERβ1 , and ERβ2) were also evaluated in livers of the animals. Dopamine concentrations were significantly higher in fish brains following bifenthrin exposure. Consistent with a reduction in dopamine clearance, there was a significant decrease in the mRNA expression of comt with increased bifenthrin concentration. Hepatic expression of ERα1 and ERβ2 mRNA was significantly decreased with increased bifenthrin concentration. These data support the possible mechanism of bifenthrin altering the dopaminergic pathway at low ng/L concentrations, in juvenile steelhead, which could interfere with endocrine feedback loops. These findings support the need for and importance of identifying species and life stage differences in pesticide modes of action to reduce uncertainties in risk assessments. [Display omitted] • Bifenthrin induces anti-estrogenic response to juvenile steelhead at ng/L dose. • Increased dopamine levels in brains of bifenthrin-exposed steelhead. • Decreased estrogen receptor expression with increased bifenthrin exposure. • Dopaminergic pathway altered in bifenthrin-exposed juvenile steelhead. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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