التفاصيل البيبلوغرافية
| العنوان: |
Decreased human sperm motility and vitality after fast gravity load changes in a parabolic flight. |
| المؤلفون: |
Perez-Poch, Antoni1,2 (AUTHOR) antoni.perez-poch@upc.edu, Ballester, Marta3 (AUTHOR), Tresanchez, Marta3 (AUTHOR), Torner, Jordi1 (AUTHOR), González, Daniel V.4 (AUTHOR), Alpiste, Francesc1 (AUTHOR), Brigos, Miguel1 (AUTHOR), Sánchez, Eduard5 (AUTHOR), Martínez, Gloria5 (AUTHOR), García, Sandra6 (AUTHOR), Polyzos, Nikolaos P.3 (AUTHOR), Boada, Montserrat3 (AUTHOR) |
| المصدر: |
Acta Astronautica. Oct2024, Vol. 223, p640-648. 9p. |
| مصطلحات موضوعية: |
*HUMAN reproductive technology, *HUMAN reproduction, *REPRODUCTIVE technology, *SPERM motility, *GAMETES, *SPERMATOZOA, *SEMEN |
| مستخلص: |
Little is known about the effects of low gravity on human gametes. The aim of this study was to analyze if fresh human sperm samples after fast gravity load changes suffered any detrimental effect in comparison to the splits maintained in Earth's gravity. Fifteen fresh samples from normozoospermic donors were analyzed. Statistically significant differences in vitality (69.7 ± 9.9 % vs 72.4 ± 9.7 %, [95 % CI: 0.002,0.07]); motile sperm concentration (23.7 ± 15.3 M/ml vs 31.5 ± 25.1 M/ml, [95 % CI: 1.03,14.65]); grade "a" sperm concentration (8.7 ± 6.5 M/ml vs 11.7 ± 9.9 M/ml, [95 % CI: 0.71,5.28]); percentage of progressive motility sperm (30 ± 12.9 % vs 36 ± 14.3 %, [95 % CI: 0.10,0.37]) and curvilinear velocity VCL: 45.7 ± 12.8 μm/s vs 47.7 ± 13.3 μm/s, [95 % CI: 0.79,3.22]) were observed. No statistical differences were observed in other sperm kinematic parameters, morphology, DNA fragmentation, apoptosis, and oxidative stress. In conclusion, even though it did not result in a total loss, heavy gravity load changes including microgravity causes a significant decrease in sperm vitality and motility suggesting that negative consequences would be even higher if the exposure were longer. The results obtained indicate that further research is really needed before Assisted Reproduction will be considered for the future human reproduction outside the Earth. • Motility and Vitality of human sperm are significantly decreased after parabolic flight including short periods of microgravity. • Curvilinear Velocity of human male gametes was particularly decreased. • No changes were found in other sperm kinematic parameters, morphology, DNA fragmentation, apoptosis and oxidative stress. • Results were found after short exposure; suggesting more negative consequences regarding human fertility in a longer time exposure. • More studies needed before Assisted Reproduction Techniques can be considered for the likelihood of Human Reproduction in Space. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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