التفاصيل البيبلوغرافية
| العنوان: |
Clinical significance of sarcopenia in children with neuroblastic tumors. |
| المؤلفون: |
Kudo, Wataru1 (AUTHOR) ccfa4833@chiba-u.jp, Terui, Keita2 (AUTHOR), Furugane, Ryoya1 (AUTHOR), Takenouchi, Ayako1 (AUTHOR), Komatsu, Shugo1 (AUTHOR), Kawaguchi, Yunosuke1 (AUTHOR), Nishimura, Katsuhiro1 (AUTHOR), Katsumi, Daisuke1 (AUTHOR), Hishiki, Tomoro1 (AUTHOR) |
| المصدر: |
Pediatric Surgery International. 8/22/2024, Vol. 40 Issue 1, p1-11. 11p. |
| مصطلحات موضوعية: |
*BODY mass index, *COMPUTED tomography, *MUSCLE mass, *SKELETAL muscle, *PROGNOSIS |
| مستخلص: |
Purpose: To elucidate the clinical significance of sarcopenia in children with neuroblastic tumors (NTs). Methods: We conducted a retrospective observational study and analyzed the z-scores for height, body weight, body mass index, and skeletal muscle index (HT-z, BW-z, BMI-z, and SMI-z) along with the clinical characteristics of 36 children with NTs. SMI-z was calculated from 138 computed tomography scans at diagnosis, during treatment, and at follow-up. The International Neuroblastoma Risk Group classification was used to identify high-risk groups. We analyzed the data at diagnosis for prognostic analysis and changes over time after diagnosis in the HT-z, BW-z, BMI-z, and SMI-z groups. Results: Among the four parameters at diagnosis, only SMI-z predicted overall survival (hazard ratio, 0.58; 95% confidence interval, 0.34–0.99). SMI-z, HT-z, and BW-z significantly decreased over time after diagnosis (P < 0.05), while BMI-z did not (P = 0.11). In surviving high-risk NT cases without disease, SMI-z, HT-z, and BW-z significantly decreased over time (P < 0.05), while BMI-z did not (P = 0.43). Conclusion: In children with NT, the SMI-z at diagnosis was a significant prognostic factor and decreased during treatment and follow-up along with HT-z and BW-z. Monitoring muscle mass is important because sarcopenia may be associated with growth impairment. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |