التفاصيل البيبلوغرافية
| العنوان: |
Intervention portfolios analysis of Plasmodium vivax control in central China. |
| المؤلفون: |
Bi, Bo1 (AUTHOR), Wu, Logan2,3,4 (AUTHOR), Liu, Ying5 (AUTHOR), Zhou, Xiao-Nong6 (AUTHOR), Shen, Tianren7,8 (AUTHOR), Cao, Li1 (AUTHOR), White, Michael9 (AUTHOR), Yang, Guo-Jing1 (AUTHOR) guojingyang@hotmail.com |
| المصدر: |
Malaria Journal. 8/13/2024, Vol. 23 Issue 1, p1-12. 12p. |
| مصطلحات موضوعية: |
*PLASMODIUM vivax, *MALARIA prevention, *MALARIA, *VECTOR control, *DRUG administration |
| مستخلص: |
Background: The effects of a diverse spectrum of malaria interventions were evaluated through a deterministic Plasmodium vivax transmission model. This approach aimed to provide theoretical evidence of the performance of these interventions once implemented for achieving malaria elimination. Methods: An integrated intervention portfolio, including mass drug administration, insecticide treatment, and untreated bed nets, was analyzed through modeling. Additionally, data-driven calibration was implemented to infer coverages that effectively reproduced historical malaria patterns in China from 1971 to 1983. Results: MDA utilizing primaquine emerged as the most effective single intervention, achieving a 70% reduction in malaria incidence when implemented at full coverage. Furthermore, a strategic combination of MDA with primaquine, chloroquine, untreated bed nets, and seasonal insecticide treatments effectively eradicated malaria, attaining elimination at a coverage level of 70%. It was conclusively demonstrated that an integrated approach combining MDA and vector control measures is essential for the successful elimination of malaria. Conclusion: High coverage of mass drug administration with primaquine and chloroquine before transmission was the key driver of the malaria decline in China from 1971 to 1983. The best-fit intervention coverage combinations derived from calibration are provided as a reference for malaria control in other countries. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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