التفاصيل البيبلوغرافية
| العنوان: |
A Double-Blinded Placebo-Controlled Randomized Trial with or without Memantine for the Prevention of Radiation-Induced Cognitive Dysfunction in Brain Metastatic Patients—CTRI/2022/01/039599: An Interim Analysis. |
| المؤلفون: |
Surendran, Haripriya1 (AUTHOR), Kavalagunta, Sruthi2 (AUTHOR), Parasuraman, Ayiramuthu2 (AUTHOR), Narmadha, Poornachary Mukunthu1 (AUTHOR), Mangalath, Sabitha1 (AUTHOR), Chandran, Dhanya2 (AUTHOR), Sasidharan, Ajay2 (AUTHOR), Dutta, Debnarayan2 (AUTHOR) |
| المصدر: |
Indian Journal of Medical & Paediatric Oncology. 2024 Supplement 1, Vol. 45, pS1-S16. 16p. |
| مصطلحات موضوعية: |
*COGNITION disorders, *MEMANTINE, *METASTASIS, *STEREOTACTIC radiosurgery, *NEUROPROTECTIVE agents |
| مستخلص: |
This article presents the findings of a double-blinded placebo-controlled randomized trial investigating the efficacy of memantine as a cognitive function protective agent for brain metastatic patients undergoing radiation therapy. The study included adult patients with brain metastases who were randomized to receive either placebo or memantine for 6 months. Cognitive scores were assessed at baseline, 16 weeks, and 24 weeks. The interim analysis showed that the memantine arm had statistically significant cognitive preservation in brain metastatic patients receiving stereotactic radiosurgery. [Extracted from the article] |
| قاعدة البيانات: |
Academic Search Index |