التفاصيل البيبلوغرافية
| العنوان: |
Regulation of the Degradation Properties of Tyrosinase-Catalyzed Crosslinking Silk Membranes for Superficial Wound Repair. |
| المؤلفون: |
Liu, Yu1 (AUTHOR) liuyu@suda.edu.cn, Liu, Xuping1 (AUTHOR), Jiao, Yuhong1 (AUTHOR), Li, Mingzhong1 (AUTHOR) liuyu@suda.edu.cn |
| المصدر: |
Materials (1996-1944). Jun2024, Vol. 17 Issue 12, p2839. 13p. |
| مصطلحات موضوعية: |
*WOUND healing, *COLLAGENASES, *SILK, *CRYSTAL structure, *AMINO acids, *PHENOL oxidase |
| مستخلص: |
Appropriate biodegradability to meet the demands of wound repair is critical for superficial wound repair membrane applications. Tyrosinase-catalyzed crosslinking SF (c-SF) membranes were constructed and regulated the degradation behavior in this study. The crosslinking degree of the c-SF membranes could be adjusted by reaction ratios of tyrosinase against SF (TYR/SF). Upon reaching a TYR/SF ratio of 20/6000, the degree of crosslinking increased to 88.17 ± 0.20%, without obvious changes in the crystal structure. The degradation behavior was regulated by the TYR/SF ratio and the degradation environment. All c-SF membranes remained stable after immersion without collagenase but showed an adjustable degradation behavior in the presence of collagenase. As the TYR/SF ratio increased, the residual weights increased from 23.31 ± 1.35% to 60.12 ± 0.82% after 7 days of degradation, occurring with low increased amounts of β-sheet structure and free amino acids. This work provides a new c-SF membrane with controllable rapid degradability and favorable cytocompatibility, which can help to meet requirements for biodegradable superficial wound repair membranes. [ABSTRACT FROM AUTHOR] |
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