التفاصيل البيبلوغرافية
| العنوان: |
Progressive multifocal leukoencephalopathy in a patient with B-cell chronic lymphocytic leukemia after COVID-19 vaccination, complicated with COVID-19 and mucormycosis: a case report. |
| المؤلفون: |
Amirifard, Hamed1,2 (AUTHOR), Shahbazi, Mojtaba1,2 (AUTHOR), Farahmand, Ghasem1 (AUTHOR), Ranjbar, Zahra1,2 (AUTHOR), Kaeedi, Maryam1,2 (AUTHOR), Heydari Havadaragh, Sanaz1,2 (AUTHOR) sanazheydari400@gmail.com |
| المصدر: |
BMC Neurology. 5/4/2024, Vol. 24 Issue 1, p1-6. 6p. |
| مصطلحات موضوعية: |
*PROGRESSIVE multifocal leukoencephalopathy, *JOHN Cunningham virus, *CHRONIC lymphocytic leukemia, *COVID-19 vaccines, *MUCORMYCOSIS, *COVID-19 pandemic, *SYMPTOMS |
| مستخلص: |
Background: Progressive multifocal leukoencephalopathy (PML) is a rare and fatal opportunistic viral demyelinating infectious disease of the central nervous system (CNS). There are various clinical presenting symptoms for the disease. Case presentation: This paper presents a clinical case of PML in a patient with B-Chronic lymphocytic leukemia (B-CLL), previously treated with Chlorambucil, later complicated later with COVID-19 and mucormycosis. Conclusion: PML can develop in the setting of cellular immune dysfunction. Late diagnosis of this disease based on nonspecific symptoms is common, therefore when we face a neurological complication in a CLL or immunocompromised patient, we should consider PML infection. A remarkable feature of this case is the possible triggering effect of COVID-19 vaccination for emergence of PML as the disease can be asymptomatic or sub-clinical before diagnosis. [ABSTRACT FROM AUTHOR] |
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