التفاصيل البيبلوغرافية
| العنوان: |
Protective Efficacy of Lyophilized Vesicular Stomatitis Virus-Based Vaccines in Animal Model. |
| المؤلفون: |
Salawudeen, Abd'jeleel1, Soule, Geoff1,2, Tailor, Nikesh2, Klassen, Levi2, Audet, Jonathan2, Sloan, Angela2, Deschambault, Yvon2, Safronetz, David1 david.safronetz@phac-aspc.gc.ca |
| المصدر: |
Emerging Infectious Diseases. May2024, Vol. 30 Issue 5, p1004-1008. 5p. |
| مصطلحات موضوعية: |
*VESICULAR stomatitis, *ANIMAL models in research, *VACCINES, *GUINEA pigs, *FREEZE-drying |
| مستخلص: |
We evaluated the in vitro effects of lyophilization for 2 vesicular stomatitis virus-based vaccines by using 3 stabilizing formulations and demonstrated protective immunity of lyophilized/reconstituted vaccine in guinea pigs. Lyophilization increased stability of the vaccines, but specific vesicular stomatitis virus-based vaccines will each require extensive analysis to optimize stabilizing formulations. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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