التفاصيل البيبلوغرافية
| العنوان: |
Only anti-GM4 antibody positivity in a Chinese girl with overlapping MFS/GBS: a case report. |
| المؤلفون: |
Chen, Jing1 (AUTHOR), Tian, Maoqiang1 (AUTHOR), Shu, XiaoMei1 (AUTHOR) Shuxiaomei1993@sina.com |
| المصدر: |
Neurological Sciences. May2024, Vol. 45 Issue 5, p2331-2335. 5p. |
| مصطلحات موضوعية: |
*ACUTE flaccid paralysis, *Q fever, *CEREBROSPINAL fluid, *GUILLAIN-Barre syndrome, *IMMUNOGLOBULINS, *DIAGNOSTIC errors |
| مستخلص: |
Background: Guillain-Barré syndrome (GBS), as the most common cause of acute flaccid paralysis worldwide, is considered a part of a clinical spectrum in which discrete, complete, or incomplete forms of GBS and overlapping syndromes lie on the basis of their clinical features. The term overlapping Miller Fisher syndrome (MFS)/GBS is used when patients with MFS also suffer from progressive motor weakness of the limbs. Anti-ganglioside GQ1b has been specifically associated with MFS and ophthalmoplegia. Case description: Here, we report a Chinese girl who was diagnosed with overlapping MFS/GBS showing acute flaccid paralysis of all four limbs, sensory symptoms, cranial nerve dysfunction, autonomic involvement, ophthalmoplegia, and ataxia. She had high serum and cerebrospinal fluid titres of monospecific anti-GM4 IgG antibody instead of anti-GQ1b antibody in the acute phase. Conclusion: Anti-GM4 antibodies usually coexist with other antiganglioside antibodies, leading to missed diagnoses. The findings of the present study show that antibodies to ganglioside GM4 may in overlapping MFS/GBS as the lone immunological factors. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |