التفاصيل البيبلوغرافية
| العنوان: |
Crosstalk between cholesterol and PIP2 in the regulation of Kv7.2/Kv7.3 channels. |
| المؤلفون: |
Delgado-Ramírez, Mayra1 (AUTHOR), López-Serrano, Ana Laura1 (AUTHOR), Sánchez-Armass, Sergio1 (AUTHOR), Meza, Ulises1 (AUTHOR), Rodríguez-Menchaca, Aldo A.1 (AUTHOR) aldo.rodriguez@uaslp.mx |
| المصدر: |
Biological Chemistry. Mar2024, Vol. 405 Issue 3, p161-165. 5p. |
| مصطلحات موضوعية: |
*ION channels, *HYDROXYCHOLESTEROLS, *CHOLESTEROL, *DEPHOSPHORYLATION |
| مستخلص: |
The activity of neuronal Kv7.2/Kv7.3 channels is critically dependent on PIP2 and finely modulated by cholesterol. Here, we report the crosstalk between cholesterol and PIP2 in the regulation of Kv7.2/Kv7.3 channels. Our results show that currents passing through Kv7.2/Kv7.3 channels in cholesterol-depleted cells, by acute application of methyl-β-cyclodextrin (MβCD), were less sensitive to PIP2 dephosphorylation strategies than those of control cells, suggesting that cholesterol depletion enhances the Kv7.2/Kv7.3–PIP2 interaction. In contrast, the sensitivity of Kv7.2/Kv7.3 channels to acute membrane cholesterol depletion by MβCD was not altered in mutant channels with different apparent affinities for PIP2. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |